N-methyl-D-aspartate receptor functions altered by neuronal PTP1B activation in Alzheimer’s disease and schizophrenia models  

作　　者：Alexandre F.R.Stewart Hsiao-Huei Chen 

机构地区：[1]Department of Biochemistry,Microbiology and Immunology,University of Ottawa,and University of Ottawa Heart Institute,Ottawa,ON,Canada [2]Centre for Infection,Immunity and Inflammation,Ottawa,ON,Canada [3]Medicine,Cellular and Molecular Medicine,University of Ottawa Brain and Mind Institute,Ottawa Hospital Research Institute,Ottawa,ON,Canada

出　　处：《Neural Regeneration Research》2022年第10期2208-2210,共3页中国神经再生研究（英文版）

基　　金：supported by grants from the Heart and Stroke Foundation of Canada(G-13-0002596&G-18-0022157,to HHC;G-16-00014085,to AFRS);Ontario Mental Health Foundation(to HHC),the Canadian Institutes of Health Research(201610PJT#376403,to HHC;201610PJT#376503,to AFRS);the Natural Science and Engineering Research Council of Canada(RGPIN/06212-2014,to HHC;RGPIN/2016-04985,to AFRS);supported by a Mid-Career Investigator Award(grant#7506)from the Heart and Stroke Foundation of Ontario.

摘　　要：Glutamate is the main exc i tatory neurotransmitter in the brain and binds to two major classes of receptors,theα-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid(AMPA)and the N-methyl-D-aspartate(NMDA)receptors.Unlike AMPA receptors that are immediately activated by glutamate release,NMDA receptors are blocked by magnesium and can only be activated by glutamate after membrane depolarization.Thus,NMDA receptors are only activated after repeated AMPA receptor activation by glutamate.NMDA receptors are,for the most part,calcium-permeable channels.Calcium influx through NMDA receptors modulates synaptic transmission in neurons based on prior history of excitation,and provides a means of scaling the strength of synapses required for Hebbian plasticity.

关 键 词：PTP1B ASPARTATE NMDA 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R749.3[医药卫生—临床医学]