CD137L,a driver of harmful inflammation in the nervous system  

作　　者：Hiu Yi Wong Amanda C.Y.Chan Anselm Mak Herbert Schwarz 

机构地区：[1]Division of Life Science,State Key Laboratory of Molecular Neuroscience,Molecular Neuroscience Center,The Hong Kong University of Science and Technology,Hong Kong Special Administrative Region,China [2]Hong Kong Center for Neurodegenerative Diseases,Hong Kong Special Administrative Region,China [3]Division of Neurology,University Medicine Cluster,National University Hospital,Singapore [4]Department of Medicine,Yong Loo Lin School of Medicine,National University of Singapore,Singapore [5]Division of Rheumatology,University Medicine Cluster,National University Health System,Department of Medicine,Yong Loo Lin School of Medicine,National Univesity of Singapore,Singapore [6]Department of Physiology,and Immunology Programme,Yong Loo Lin School of Medicine,National University of Singapore,Singapore [7]Integrative Sciences and Engineering Programme,NUS Graduate School,National University of Singapore,Singapore

出　　处：《Neural Regeneration Research》2023年第11期2387-2388,共2页中国神经再生研究（英文版）

摘　　要：CD137 (TNFRSF9,4-1BB) is a member of the tumor necrosis factor (TNF) receptor family and a potent costimulatory molecule.High levels of CD137 are expressed on T cells upon activation.CD137 signaling in T cells,either by cognate interaction with antigen-presenting cells (APC)or by agonistic anti-CD137 antibodies,strongly enhances proliferation,interferon-y secretion,and cytolytic activity of T cells.Thus,CD137 signaling is a main driver of cellular,type 1 helper T cells (Th1)and type 1 cytolytic T cells (Tc1) polarised immune responses.

关 键 词：CD137 CD137L INFLAMMATION 

分 类 号：R741.02[医药卫生—神经病学与精神病学]