Combination of novel RNA sequencing and sophisticated network modeling to reveal a common denominator in amyotrophic lateral sclerosis?  

作　　者：Banaja P.Dash Andreas Hermann 

机构地区：[1]Translational Neurodegeneration Section“Albrecht Kossel”,Department of Neurology,University Medical Center Rostock,Rostock,Germany [2]Center for Transdisciplinary Neurosciences Rostock,University Medical Center Rostock,Rostock,Germany [3]Deutsches Zentrum für Neurodegenerative Erkrankungen(DZNE)Rostock/Greifswald,Rostock,Germany

出　　处：《Neural Regeneration Research》2023年第11期2403-2405,共3页中国神经再生研究（英文版）

基　　金：Hermann und Lilly Schilling Stiftung für Medizinische Forschung im Stifterverbond (to AH)。

摘　　要：Amyotrophic lateral sclerosis (ALS) is one of the most dreadful neurodegenerative diseases leading to death within 1-5 years after symptom onset.The majority of ALS cases are sporadic(sALS),while the remaining 5-10%are familial(fALS).Genetic discoveries have identified ALScausative mutations in more than 30 genes so far(Chia et al.,2018).Indeed,the four most common mutations observed in ALS genes in Europe are the hexanucleotide expansion repeat in Chromosome9 Open Reading Frame 72 (C9ORF72),Cu-Zn superoxide dismutase 1 (SOD1),tra nsactive response DNA Binding protein 43kDa (TARDBP)and fused in sa rcoma (FUS).

关 键 词：DISEASES DEATH 

分 类 号：R744.8[医药卫生—神经病学与精神病学]