细胞自噬对肝脏疾病代谢的调节作用研究进展  

Research progress of the regulatory role of autophagy in metabolic liver diseases

作　　者：李玉贤 任锋[2] 陈煜 Li Yuxian;Ren Feng;Chen Yu(Beijing Institute of Technology,Beijing 100081,China;Beijing Institute of Hepatology,Beijing YouAn Hospital,Capital Medical University,Beijing 100069,China;Intractable Hepatic Diseases and Artificial Liver Treatment&Training Center&Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment,Beijing 100069,China)

机构地区：[1]北京理工大学,北京100081 [2]首都医科大学附属北京佑安医院、北京市肝病研究所,北京100069 [3]疑难肝病及人工肝中心、肝衰竭与人工肝治疗研究北京市重点实验室,北京100069

出　　处：《中华肝脏病杂志》2023年第1期105-108,共4页Chinese Journal of Hepatology

基　　金：国家自然科学基金(81770611);北京自然科学基金和北京市教委联合资助重点项目(KZ202010025035);首都卫生发展科研专项重点攻关项目(首发2020-1-1151);北京市科技计划"首都临床诊疗技术研究及示范应用"专项课题(Z191100006619096、Z191100006619097);科技部传染病重大专项项目(2018ZX10301407-005-002、2018ZX10302205-004-004)。

摘　　要：细胞自噬参与到多种肝脏代谢中,为饥饿的细胞提供氨基酸、游离脂肪酸和葡萄糖,用于新的大分子的能源生产和合成,同时自噬还控制着线粒体等细胞器的质量和数量。肝脏作为机体重要的代谢器官,细胞自噬的多种特异性变异是维持肝脏稳态的关键,不同的肝脏疾病会引起蛋白质、脂肪、糖三大营养物质的代谢变化。调节细胞自噬的药物,可以通过增强或者减少细胞自噬,从而使肝脏疾病时三大营养物质的代谢增强或减弱,为肝脏疾病的治疗开创新的途径。Autophagy is one of several hepatic metabolic processes in which starved cells are supplied with glucose,free fatty acids,and amino acids to produce energy and synthesize new macromolecules.Moreover,it regulates the quantity and quality of mitochondria and other organelles.As the liver is a vital metabolic organ,specific forms of autophagy are necessary for maintaining liver homeostasis.Protein,fat,and sugar are the three primary nutrients that can be altered by different metabolic liver diseases.Drugs that have an effect on autophagy can either promote or inhibit autophagy,and as a result,it can either increase or inhibit the three major nutritional metabolisms that are affected by liver disease.Thus,this opens up a novel therapeutic option for liver disease.

关 键 词：细胞自噬 肝脏疾病 代谢调节 

分 类 号：R575[医药卫生—消化系统]