How sugar instigates macrophages to be evils in tumor  

作　　者：Houjun Xia Youhai H.Chen 

机构地区：[1]Center for Cancer Immunology,Institute of Biomedicine and Biotechnology,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,China

出　　处：《Cellular & Molecular Immunology》2022年第12期1325-1327,共3页中国免疫学杂志（英文版）

基　　金：supported in part by grants from the Shenzhen Institute of Advanced Technology (HX) and the National Natural Science Foundation of China (No.32130040) (YHC).

摘　　要：In a recent issue of the journal Cancer Cell,Shi et al.reported that glucose metabolism remodels pro-tumoral functions of tumor-associated macrophages(TAMs)to support cancer metastasis and chemoresistance.Mechanistically,the consumption of glucose fuels hexosamine biosynthetic pathway(HBP)and enhances O-GlcNAcylation of Cathepsin B in macrophages,which upon secretion disrupts the tumor microenvironment(TME)[1].

关 键 词：METABOLISM TUMOR 

分 类 号：R730[医药卫生—肿瘤]