鹰嘴豆多肽抗疲劳活性  

Study on the anti-fatigue activity of chickpea peptide

作　　者：董静茹 莫君明 王升 DONG Jing-ru;MO Jun-ming;WANG Sheng(Guangxi University for Nationalities,Nanning,Guangxi 530006,China;State Ethnic Affairs Commission Key Laboratory of Chemistry and Engineering of Forest Products,Guangxi University for Nationalities,Nanning,Guangxi 530006,China;Guangxi Key Laboratory of Chemistry and Engineering of Forest Products,Nanning,Guangxi 530006,China;Guangxi Collaborative Innovation Center for Chemistry and Engineering of Forest Products,Nanning,Guangxi 530006,China;Nanning Pangbo Biological Engineering Co.,Ltd.,Nanning,Guangxi 530031,China)

机构地区：[1]广西民族大学化学化工学院,广西南宁530006 [2]广西民族大学林产化学与工程国家民委重点实验室,广西南宁530006 [3]广西民族大学广西林产化学与工程重点实验室,广西南宁530006 [4]广西民族大学广西林产化学与工程协同创新中心,广西南宁530006 [5]南宁庞博生物工程有限公司,广西南宁530031

出　　处：《食品与机械》2023年第3期142-146,共5页Food and Machinery

基　　金：国家自然科学基金青年科学基金项目(编号:21701035);广西高校引进海外高层次人才“百人计划”(编号:桂教人〔2016〕59号)。

摘　　要：目的:提高鹰嘴豆的附加值。方法:进行小鼠负重游泳试验,测定免疫活性,分析疲劳相关生化指标。结果:负重游泳试验中,鹰嘴豆多肽喂养组小鼠游泳时间极显著长于对照组(P<0.01),鹰嘴豆多肽极显著降低了小鼠血液中尿素氮和血乳酸水平,极显著提高了肝糖原、肌糖原和胰岛素含量(P<0.01)。鹰嘴豆多肽还可显著提高超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-Px)、乳酸脱氢酶(LDH)的活性。此外,补充鹰嘴豆多肽可以通过增加小鼠的吞噬细胞活性、刺激sIgA分泌和减少促炎细胞因子来提高免疫力。结论:鹰嘴豆多肽对小鼠具有较强的抗疲劳作用。Objective:This study aimed to investigate the anti-fatigue activity of chickpea polypeptide and its anti-fatigue mechanism.Methods:Weight-bearing swimming test,fatigue-related biochemical index analysis and immune activity determination were analyzed in mice.Results:In the weight-bearing swimming test,the swimming time of the chickpea polypeptide-fed group was significantly longer than that of the control group(P<0.01).The test results of biochemical indicators showed that chickpea polypeptide significantly reduced the levels of urea nitrogen and blood lactic acid in the blood of mice,and also significantly increased the contents of liver glycogen,muscle glycogen and insulin(P<0.01).Chickpea polypeptide also significantly improved the activities of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)and lactate dehydrogenase(LDH).In addition,chickpea polypeptide supplementation improved the immunity by increasing phagocyte activity,stimulating sIgA secretion and reducing proinflammatory cytokines in mice.Conclusion:Chickpea polypeptide has a strong anti-fatigue effect on mice.

关 键 词：鹰嘴豆 抗疲劳活性 多肽 免疫调节 

分 类 号：TS218[轻工技术与工程—粮食、油脂及植物蛋白工程]