Pembrolizumab combined with axitinib in the treatment of skin metastasis of renal clear cell carcinoma to nasal ala:A case report  

作　　者：Shuai Dong Yang-Chun Xu Yuan-Chen Zhang Jian-Xin Xia Yan Mou 

机构地区：[1]Department of Dermatology,The Second Hospital of Jilin University,Changchun 130041,Jilin Province,China

出　　处：《World Journal of Clinical Cases》2023年第9期2104-2109,共6页世界临床病例杂志

基　　金：Supported by the National Natural Science Foundation of China,No.81803160.

摘　　要：BACKGROUND Renal clear cell carcinoma(RCC)is a malignant tumor of the genitourinary system with a predilection for males.The most common metastatic sites are the lung,liver,lymph nodes,contralateral kidney or adrenal gland,however,skin metastasis has only been seen in 1.0%-3.3%of cases.The most common site of skin metastasis is the scalp,and metastasis to the nasal ala region is rare.CASE SUMMARY A 55-year-old man with clear cell carcinoma of the left kidney was treated with pembrolizumab and axitinib for half a year after surgery and was found to have a red mass on his right nasal ala for 3 mo.The skin lesion of the patient grew rapidly to the size of 2.0 cm×2.0 cm×1.2 cm after discontinuation of targeted drug therapy due to the coronavirus disease 2019 epidemic.The patient was finally diagnosed with skin metastasis of RCC in our hospital.The patient refused to undergo surgical resection and the tumor shrank rapidly after resuming target therapy for 2 wk.CONCLUSION It is rare for an RCC to metastasize to the skin of the nasal ala region.The tumor size change of this patient before and after treatment with targeted drugs shows the effectiveness of combination therapy for skin metastasis.

关 键 词：Skin metastasis Renal clear cell carcinoma Pembrolizumab AXITINIB Case report 

分 类 号：R737.11[医药卫生—肿瘤]