Precision medicine in inflammatory bowel disease:Individualizing the use of biologics and small molecule therapies  

作　　者：Eric Cheah James Guoxian Huang 

机构地区：[1]Department of Gastroenterology and Clinical Nutrition,The Royal Children's Hospital Melbourne,Parkville,VIC 3052,Australia [2]Department of Paediatrics,Khoo Teck Puat-National University Children's Medical Institute,National University Health System,Singapore 119228,Singapore [3]Department of Paediatrics,Yong Loo Lin School of Medicine,National University of Singapore,Singapore 119228,Singapore

出　　处：《World Journal of Gastroenterology》2023年第10期1539-1550,共12页世界胃肠病学杂志（英文版）

摘　　要：The advent of biologics and small molecules in inflammatory bowel disease(IBD)has marked a significant turning point in the prognosis of IBD,decreasing the rates of corticosteroid dependence,hospitalizations and improving overall quality of life.The introduction of biosimilars has also increased affordability and enhanced access to these otherwise costly targeted therapies.Biologics do not yet represent a complete panacea:A subset of patients do not respond to first-line anti-tumor necrosis factor(TNF)-alpha agents or may subsequently demonstrate a secondary loss of response.Patients who fail to respond to anti-TNF agents typically have a poorer response rate to second-line biologics.It is uncertain which patient would benefit from a different sequencing of biologics or even a combination of biologic agents.The introduction of newer classes of biologics and small molecules may provide alternative therapeutic targets for patients with refractory disease.This review examines the therapeutic ceiling in current treatment strategies of IBD and the potential paradigm shifts in the future.

关 键 词：Precision medicine Therapeutic ceiling Inflammatory bowel disease BIOLOGICS Small molecules 

分 类 号：R574[医药卫生—消化系统]