NLR、PLR与高级别浆液性卵巢癌分期、BRCA突变及淋巴结转移、HRD状态的关系  

Correlation of NLR and PLR with stage,BRCA mutation,lymph node metastasis and homologous recombination deficiency status in high-grade serous ovarian cancer

作　　者：刘璐雯 邓思思 周晴晴 陈双凤 李敏[1] 张天骄 周颖[1] LIU Lu-wen;DENG Si-si;ZHOU Qing-qing;CHEN Shuang-feng;LI Min;ZHANG Tian-jiao;ZHOU Ying(Department of Obstetrics and Gynecology,the First Affiliated Hospital of USTC,Division of Life Sciences and Medeicine,University of Science and Technology of China,Hefei 230001,China)

机构地区：[1]中国科学技术大学附属第一医院(安徽省立医院)妇产科,合肥230001

出　　处：《临床与实验病理学杂志》2023年第3期261-264,270,共5页Chinese Journal of Clinical and Experimental Pathology

基　　金：安徽省重点研发计划(2022e07020013);安徽省自然科学基金(2208085QH252);2020年院医疗领先技术引进项目(2020LXJS-05)。

摘　　要：目的探讨中性粒细胞与淋巴细胞比值(neutrophil-to-lymphocyte ratio,NLR)、血小板与淋巴细胞比率(platelet-to-lymphocyte ratio,PLR)与高级别浆液性卵巢癌(high-grade serous ovarian cancer,HGSOC)分期、淋巴结转移、BRCA1/2基因突变及同源重组修复缺陷(homologous recombination deficiency,HRD)状态的相关性。方法依据入组及排除标准,回顾性分析152例有BRCA1/2基因检测以及47例有HRD检测结果的HGSOC基本临床信息,根据FIGO(2018)分期、BRCA1/2基因是否突变、HRD状态、淋巴结是否转移分组,分析NLR、PLR与不同因素的相关性。结果与早期HGSOC相比,晚期HGSOC患者中NLR(P=0.004,cut off=2.085)、PLR(P<0.001,cut off=167.1)显著升高;与淋巴结转移阴性HGSOC患者相比,淋巴结转移阳性患者的CA125水平显著升高(P<0.001)。结论NLR、PLR与HGSOC患者分期显著相关,与淋巴结转移、BRCA1/2突变状态、HRD状态无相关性。Purpose To explore the correlation between neutrophil-to-lymphocyte ratio(NLR)and platelet to lymphocyte ratio(PLR)with the stage,lymph node metastasis,BRCA1/2 gene and homologous recombination deficiency(HRD)status of high-grade serous ovarian cancer(HGSOC).Methods According to the inclusion and exclusion criteria,the basic clinical information of 152 patients with BRCA1/2 gene detection and 47 patients with HRD detection results analyzed.According to the FIGO(2018)stage,grouped by BRCA1/2 gene mutation status,HRD status and lymph node metastasis,this study analyzed the correlation between NLR,PLR and different factors.Results Compared with the early HGSOC patients,NLR(P=0.004,cut off=2.085)and PLR(P<0.001,cut off=167.1)were significantly increased in the late HGSOC patients.In addition,compared with HGSOC patients with negative lymph node metastasis,CA125 in patients with positive lymph node metastasis was significantly increased(P<0.001).Conclusion NLR and PLR are significantly correlated with the stage of HGSOC patients,but not with lymph node metastasis,BRCA1/2 mutation status and HRD status.

关 键 词：卵巢肿瘤 卵巢高级别浆液性癌 NLR PLR BRCA1/2 HRD 

分 类 号：R737.31[医药卫生—肿瘤]