Swertiamarin ameliorates diet-induced obesity by promoting adipose tissue browning and oxidative metabolism in preexisting obese mice  

作　　者：Yuqin Zhu Haoran Li Mengchen Ma Dandan Li Ouyang Zhang Suili Cai Yajiao Wang Dandan Chen Shengnan Jin Chunming Ding Liang Xu 

机构地区：[1]School of Laboratory Medicine and Life Sciences,Wenzhou Medical University,Wenzhou 325035,China [2]Key Laboratory of Laboratory Medicine,Ministry of Education,Wenzhou Medical University,Wenzhou 325035,China

出　　处：《Acta Biochimica et Biophysica Sinica》2023年第1期131-142,共12页生物化学与生物物理学报（英文版）

基　　金：This work was supported by the grants from the National Natural Science Foundation of China(No.81900778 to L.X.);the Zhejiang Provincial Natural Science Foundation of China(No.LY21H070004 to L.X.);the Wenzhou Municipal Science and Technology Bureau(No.Y20190049 to L.X.);the High-Level Innovation Team of Universities in Zhejiang Province(No.604090352/610 to C.D.).

摘　　要：Obesity is a risk factor for many metabolic diseases.Efficient therapeutic strategies are urgently needed.Swertiamarin(STM)prevents obesity and the associated insulin resistance and inflammation.However,the therapeutic effects of STM on preexisting obesity remain unclear.Therefore,in this study we aim to investigate the effects of STM on energy expenditure and fat browning in mice with preexisting obesity.C57BL/6J mice are fed with a high-fat diet(HFD)for 8 weeks to induce obesity and then gavaged(or not)with STM for 10 weeks.The whole-body energy metabolism of mice is examined by indirect calorimetry.The results show that after 10 weeks of treatment,STM markedly prevents HFD-induced weight gain,chronic inflammation,insulin resistance,and hepatic steatosis.STM promotes oxygen consumption and energy expenditure.The level of uncoupling protein 1 is enhanced in the brown and white adipose tissues of STM-treated mice.STM increases the phosphorylation of AMP-activated protein kinase and the expressions of genes involved in fat oxidation,reducing fat deposition in skeletal muscles.Meanwhile,STM does not affect the intestinal microbiotic composition.Overall,STM supplementation may serve as a potential therapy for obesity.

关 键 词：OBESITY SWERTIAMARIN fat browning energy expenditure fatty acid oxidation 

分 类 号：R589.2[医药卫生—内分泌]