SWERTIAMARIN

作品数：7被引量：13H指数：2
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相关领域：医药卫生更多>>
相关作者：吴兴旺魏朔南更多>>
相关机构：安徽医科大学安徽医科大学第一附属医院西北大学更多>>
相关期刊：《Acta Biochimica et Biophysica Sinica》《Chinese Herbal Medicines》《World Journal of Diabetes》《南方医科大学学报》更多>>
相关基金：国家自然科学基金更多>>
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Swertiamarin通过抑制肠上皮细胞细胞凋亡改善TNBS诱导的实验性结肠炎
《南方医科大学学报》2024年第8期1545-1552,共8页刘硕 李静 吴兴旺 
安徽省高校优秀青年基金(2022AH030138);安徽省自然科学基金(2308085MH241);安徽省学术和技术带头人及后备人选科研活动经费资助项目(2021D299)。
目的本研究旨在探讨Swertiamarin(STM)通过拮抗肠上皮细胞凋亡改善CD样结肠炎的作用和机制。方法体外建立TNF-α刺激的Caco-2细胞凋亡模型,分为3组:对照组(Con)、TNF-α刺激组(TNF-α)和STM干预组(STM),通过Tunel染色、免疫印迹、免疫...
关键词：克罗恩病 肠屏障 肠上皮细胞凋亡 SWERTIAMARIN PI3K/AKT通路 
Förster resonance energy transfer reveals phillygenin and swertiamarin concurrently target AKT on different binding domains to increase the anti-inflammatory effect
《Chinese Chemical Letters》2024年第5期207-212,共6页Xiaoyao Ma Jinling Zhang Ge Fang He Gao Jie Gao Li Fu Yuanyuan Hou Gang Bai 
supported by the National Natural Science Foundation of China(No.81973449).
The clinical benefit of combination therapy is significant,but it is not easy to define the mechanism of complexity and diversity.Previous studies illustrate that phillygenin(Phi)binds in the allosteric inhibit pocket...
关键词：FRET SWERTIAMARIN Phillygenin AKT ANTI-INFLAMMATION Combinatorial drug 
Lomatogonium rotatum extract alleviates diabetes mellitus induced by a high-fat,high-sugar diet and streptozotocin in rats
《World Journal of Diabetes》2023年第6期846-861,共16页Li-Li Dai Sung-Bo Cho Hui-Fang Li Li-Sha A Xiao-Ping Ji Sirigunqiqige Pan Ming-Lan Bao Laxinamujila Bai Gen-Na Ba Ming-Hai Fu 
Supported by the National Natural Science Foundation of China,No.82260773 and 81803845;Central Government Guided Local Scientific and Technological Development Project,No.2021ZY0015;Science and Technology Young Talents Development Project of Inner Mongolia Autonomous Region,No.NJYT22048.
BACKGROUND Lomatogonium rotatum(LR)is traditionally used in Mongolian folk medicine as a hypoglycemic agent,but its evidence-based pharmacological effects and mechanisms of action have not been fully elucidated.AIM To...
关键词：Mongolian medicine Lomatogonium rotatum Type 2 diabetes Metabolomics SWERTIAMARIN STREPTOZOTOCIN 
Pharmacokinetics of nitrogen-containing metabolites R-gentiandiol and S-gentiandiol in rat plasma after oral administration of swertiamarin
《Journal of Hainan Medical University》2023年第6期22-27,共6页LI Peng-yu CUI Fu-yan HUANG Jin-yue TANG Meng JIANG Jia-xin MA Ying XIA Nian-tong YANG Bo WANG Zhi-gang 
This study was supported by Key Research and Development Guidance Program of Heilongjiang Province(GZ20210125)。
Objective:A chiral resolution method for enantiomers of two chiral nitrogen-containing metabolites R-gentiandiol and S-gentiandiol of swertiamarin in plasma was developed,and the pharmacokinetics of the metabolites we...
关键词：SWERTIAMARIN METABOLITE R-gentiandiol S-gentiandiol PHARMACOKINETICS 
Swertiamarin ameliorates diet-induced obesity by promoting adipose tissue browning and oxidative metabolism in preexisting obese mice被引量：1
《Acta Biochimica et Biophysica Sinica》2023年第1期131-142,共12页Yuqin Zhu Haoran Li Mengchen Ma Dandan Li Ouyang Zhang Suili Cai Yajiao Wang Dandan Chen Shengnan Jin Chunming Ding Liang Xu 
This work was supported by the grants from the National Natural Science Foundation of China(No.81900778 to L.X.);the Zhejiang Provincial Natural Science Foundation of China(No.LY21H070004 to L.X.);the Wenzhou Municipal Science and Technology Bureau(No.Y20190049 to L.X.);the High-Level Innovation Team of Universities in Zhejiang Province(No.604090352/610 to C.D.).
Obesity is a risk factor for many metabolic diseases.Efficient therapeutic strategies are urgently needed.Swertiamarin(STM)prevents obesity and the associated insulin resistance and inflammation.However,the therapeuti...
关键词：OBESITY SWERTIAMARIN fat browning energy expenditure fatty acid oxidation 
Anti-mutagenicity of Swertiamarin and Its Metabolite in Incubated System of Human Intestinal Flora被引量：4
《Chinese Herbal Medicines》2017年第1期92-95,共4页Cheng-wang Tian Ya-ting Cheng Tie-jun Zhang Xiu-wei Yang 
National Natural Science Foundation of China(81001627);Tianjin Science and Technology Development Fund(11ZCKFSY01200)
Objective To study the biotransformation regulation and pharmacological effect of swertiamarin and its metabolite in incubated system of human intestinal flora. Methods Incubated system of human intestinal flora was u...
关键词：anti-mutagenicity BIOTRANSFORMATION human intestinal flora SWERTIAMARIN 
Chemical fingerprint analysis of Gentianae Radix et Rhizoma by high-performance liquid chromatography被引量：8
《Acta Pharmaceutica Sinica B》2012年第1期46-52,共7页Baozhong Duan Jianyong Hu Linfang Huang Xianying Yang Fuying Chen 
supported by Key National Science Foundation of China(81130069);Beijing Tongrentang Co.Ltd.(D08080203640901);the State Key Laboratory of Traditional Chinese Medicine Resources Research and Development in Chendu University of TCM。
Gentianae Radix et Rhizoma(also called "Longdan" in Chinese)is commonly used for eliminating damp-heat and quenching the fire of liver and gall bladder in traditional Chinese medicine.In this study,a novel and reliabl...
关键词：Gentianae Radix et Rhizoma Loganic acid SWERTIAMARIN GENTIOPICROSIDE Sweroside HPLC Quantitative determination FINGERPRINT Quality control 
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