GENTIOPICROSIDE

作品数：13被引量：60H指数：5
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相关领域：医药卫生更多>>
相关作者：李艳秋邓伟峰蔡少青马晓庆洪浩更多>>
相关机构：西北大学北京大学怀化医学高等专科学校第四军医大学更多>>
相关期刊：《World Journal of Traditional Chinese Medicine》《Chinese Herbal Medicines》《Chinese Journal of Integrative Medicine》《Chinese Journal of Natural Medicines》更多>>
相关基金：国家自然科学基金广东省自然科学基金更多>>
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Gentiopicroside Alleviates Atherosclerosis by Suppressing Reactive Oxygen Species-Dependent NLRP3 Inflammasome Activation in Vascular Endothelial Cells via SIRT1/Nrf2 Pathway
《Chinese Journal of Integrative Medicine》2025年第2期118-130,共13页LI Zhu-qing ZHANG Feng LI Qi WANG Li SUN Xiao-qiang LI Chao YIN Xue-mei LIU Chun-lei WANG Yan-xin DU Xiao-yu LU Cheng-zhi 
Supported by the National Natural Science Foundation of China(No.82300445);the Natural Science Foundation of Tianjin(No.22JCQNJC01130);the Medical Health Science and Technology Project of Tianjin Municipal Health Commission(No.TJWJ2023QN026)。
Objective:To evaluate the protective effects of gentiopicroside(GPS)against reactive oxygen species(ROS)-induced NOD-like receptor family,pyrin domain containing 3(NLRP3)inflammasome activation in endothelial cells,ai...
关键词：endothelial dysfunction GENTIOPICROSIDE NLRP3 inflammasome SIRT1 nuclear factor erythroid 2-related factor 2 Chinese medicine 
Gentiopicroside targets PAQR3 to activate the PI3K/AKT signaling pathway and ameliorate disordered glucose and lipid metabolism被引量：18
《Acta Pharmaceutica Sinica B》2022年第6期2887-2904,共18页Haiming Xiao Xiaohong Sun Zeyuan Lin Yan Yang Meng Zhang Zhanchi Xu Peiqing Liu Zhongqiu Liu Heqing Huang 
supported by research grants from the National Natural Science Foundation of China (No.81770816 and 81973375);the Key Project of Natural Science Foundation of Guangdong Province,China (No.2017A030311036);Seed Program of Guangdong Province (No.2017B090903004,China);Guangdong Provincial Key Field and Program Project (No.2020B1111100004,China)。
The obstruction of post-insulin receptor signaling is the main mechanism of insulin-resistant diabetes.Progestin and adipoQ receptor 3(PAQR3),a key regulator of inflammation and metabolism,can negatively regulate the ...
关键词：GENTIOPICROSIDE Insulin resistance PAQR3 PI3K/AKT DDB2 UBIQUITYLATION Glucose metabolism disorder Lipid metabolism disorder 
Synthesis,and anti-inflammatory activities of gentiopicroside derivatives被引量：3
《Chinese Journal of Natural Medicines》2022年第4期309-320,共12页ZHANG Qi-Li XIA Peng-Fei PENG Xue-Jing WU Xiao-Yu JIN Hua ZHANG Jian ZHAO Lei 
This work was supported by the National Natural Science Foundation of China(Nos.82160457 and 81660577);the Natural Science Foundation of Gansu Province(No.21JR7RA564).
A series of 26 novel derivatives have been synthesized through structural modification of gentiopicroside,a lead COX-2 inhibitor.And their in vivo and in vitro anti-inflammatory activities have been investigated.The i...
关键词：Gentiopicroside derivatives Structural modification Anti-inflammatory activity Selective inhibitors 
The Distribution,Uses,and Characteristic Components of Gentianaceae Plants in China
《World Journal of Traditional Chinese Medicine》2021年第3期287-298,共12页Han Cheng Yue-Bin Ge Jun Li Yan Zhang Xian-Ju Huang Guo-Xun Chen 
support from Research project of the National Natural Science Foundation of China(No.81873090,81374064);the Fundamental Research Funds for the Central Universities,South-Central University for Nationalities(CZP20002)。
Extracts of Gentianaceae herbs have been widely used as food additives,teas,or medicinal remedies for various human diseases and disorders.Iridoids,secoiridoids,and analogs glycosides,mainly include gentiopicroside,sw...
关键词：ANALOGS GENTIOPICROSIDE IRIDOIDS PHYTOMEDICINES secoiridoids 
Anti-inflammatory activities of gentiopicroside against iNOS and COX-2 targets被引量：8
《Chinese Herbal Medicines》2019年第1期108-112,共5页Qi-li Zhang Jian Zhang Peng-fei Xia Xue-jing Peng Hai-long Li Hua Jin Yang Li Jie Yang Lei Zhao 
supported by the National Natural Science Foundation of China (No.81660577, No.21562001, and No.81560716);Natural Science Foundation of Gansu Province (1506RJZA036 and 148RJZA064)
Objective: To isolate high-purity gentiopicroside from the Chinese herbal Gentiana officinalis and investigate its anti-inflammatory activity against iNOS and COX-2 targets.Methods: The purity and structures of gentio...
关键词：ANTI-INFLAMMATORY activity CYCLOOXYGENASE-2 GENTIOPICROSIDE INDUCIBLE NITRIC oxide SYNTHASE inflammation target 
Gentiopicroside ameliorates LKB1/AMPK-dependent alcoholic hepatosteatosis via P2x7R-NLRP3 inflammasome被引量：3
《中国药理学与毒理学杂志》2018年第4期265-266,共2页Xia LI Yu ZHANG Kai-li XIA Min JIANG Ben-wen CUI Yan-ling WU Ji-xing NAN Li-hua LIAN 
supported by National Natural Science Foundation of China(81560597;81260664;81360658;81660689)
OBJECTIVE Regulating P2x7R-NLRP3 inflammasome activation might be a potential therapeutic strategy to treat alcoholic hepatosteatosis.We investigated whether this process would be modulated by gentiopicroside(GPS),whi...
关键词：炎症 酒精肝 治疗方法 临床分析 
Gentiopicroside, originated from Gentiana macrophylla Pall, possesses antiarthritic efficacy in adjuvant-induced arthritis rats被引量：1
《中国药理学与毒理学杂志》2018年第4期287-287,共1页Ya-nan HUAN Lei-ming ZHANG Yong-ying LU Mei-ling WANG Yan-fei HAO Mao-jing ZHU Feng-hua FU 
OBJECTIVE This work aimed to investigate the anti-rheumatoid arthritic effect of gentio.picroside from Gentiana macrophylla Pall using an animal model of adjuvant induced arthritis.METH.ODS Adjuvant arthritis was indu...
关键词：关节炎 风湿 治疗方法 中医 
Gentiopicroside alleviates alcoholic fatty liver through suppression of P2X7r-Caspapse-1 pathway
《中国药理学通报》2015年第B11期62-63,共2页
Aim To investigate the protective effects of gentiopicroside （GPS） on acute alcohol-induced fatty liver.Methods Mice were treated with ethanol （5 g · kg^-11 of body weight） by gavage every 12 h for a total of thr...
关键词：GENTIOPICROSIDE ALCOHOLIC STEATOSIS AMPK LKB1 SREBP-1 P2X7r caspase-1 IL-1β 
Changes of Secondary Metabolites and Trace Elements in Gentiana macrophylla Flowers: A Potential Medicinal Plant Part被引量：5
《Chinese Herbal Medicines》2014年第2期145-151,共7页Xiao-xue Niu Xiao-wen Chen He Su A.Egrinya Eneji Yu-hai Guo Xue-hui Dong 
Major National Science and Technology Program(2009ZX09308)
Objective To search for the potential medicinal plant part of Gentiana macrophyllabased on changes of secondary metabolites and trace elements in the flowers of G.macrophylla.Methods HPLC was used to detect the change...
关键词：flower development Gentiana macrophylla Gentianaceae gentiopicroside longanic acid trace elements 
Chemical fingerprint analysis of Gentianae Radix et Rhizoma by high-performance liquid chromatography被引量：8
《Acta Pharmaceutica Sinica B》2012年第1期46-52,共7页Baozhong Duan Jianyong Hu Linfang Huang Xianying Yang Fuying Chen 
supported by Key National Science Foundation of China(81130069);Beijing Tongrentang Co.Ltd.(D08080203640901);the State Key Laboratory of Traditional Chinese Medicine Resources Research and Development in Chendu University of TCM。
Gentianae Radix et Rhizoma(also called "Longdan" in Chinese)is commonly used for eliminating damp-heat and quenching the fire of liver and gall bladder in traditional Chinese medicine.In this study,a novel and reliabl...
关键词：Gentianae Radix et Rhizoma Loganic acid SWERTIAMARIN GENTIOPICROSIDE Sweroside HPLC Quantitative determination FINGERPRINT Quality control 
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