不同焦虑程度青少年首发广泛性焦虑障碍患者血清NPY、5-HT、BDNF的变化及其与生活应激、炎症因子和记忆功能的相关性分析  

Changes of Serum NPY,5-HT,BDNF and Their Correlation Analysis with Life Stress,Inflammatory Factors and Memory Function in First-Episode Generalized Anxiety Disorder of Adolescents with Different Anxiety Levels

作　　者：何旭斌 宦宗素 余芹瑶 杜娜 岳玉川[4] HE Xu-bin;HUAN Zong-su;YU Qin-yao;DU Na;YUE Yu-chuan(Graduate School of Zunyi Medical University,Zunyi,Guizhou,563006,China;Department of Psychosomatic Medicine,Chengdu Mental Health Center,Chengdu,Sichuan,610036,China;Department of Pharmacy,Chongqing Medical School,Chongqing,401228,China;Administration Section,Chengdu Mental Health Center,Chengdu,Sichuan,610036,China)

机构地区：[1]遵义医科大学研究生院,贵州遵义563006 [2]成都市精神卫生中心心身医学科,四川成都610036 [3]重庆市医药学校药学系,重庆401228 [4]成都市精神卫生中心行政科,四川成都610036

出　　处：《现代生物医学进展》2023年第4期777-781,共5页Progress in Modern Biomedicine

基　　金：四川省医学科研青年创新课题(Q20017)。

摘　　要：目的:探讨不同焦虑程度青少年首发广泛性焦虑障碍(GAD)患者血清神经肽Y(NPY)、5-羟色胺(5-HT)、脑源性神经营养因子(BDNF)的变化及其与生活应激、炎症因子和记忆功能的相关性。方法:选择2019年1月至2021年12月成都市精神卫生中心收治的147例青少年首发GAD患者,根据广泛性焦虑量表(GAD-7)分为轻度焦虑组(5-9分,50例)、中度焦虑组(10-14分,65例)、重度焦虑组(15-21分,32例)。检测血清NPY、5-HT、BDNF、C反应蛋白(CRP)、白细胞介素(IL)-1α、IL-6水平,采用学生生活应激问卷(SLSI)、延迟匹配测验(DMS)评估生活应激水平和记忆功能。比较组间血清NPY、5-HT、BDNF、CRP、IL-1α、IL-6水平以及SLSI、DMS差异,分析血清NPY、5-HT、BDNF水平与血清CRP、IL-1α、IL-6水平及SLSI、DMS的相关性。结果:重度焦虑组血清NPY、5-HT、BDNF水平低于中度焦虑组和轻度焦虑组(P<0.05),且中度焦虑组低于轻度焦虑组(P<0.05),重度焦虑组CRP、IL-1α、IL-6水平以及SLSI评分高于中度焦虑组和轻度焦虑组(P<0.05),且中度焦虑组高于轻度焦虑组(P<0.05)。重度焦虑组总延迟反应时间、无延迟反应时间长于中度焦虑组和轻度焦虑组(P<0.05),且中度焦虑组长于轻度焦虑组(P<0.05);重度焦虑组总延迟正确数、无延迟正确数少于中度焦虑组和轻度焦虑组(P<0.05),且中度焦虑组少于轻度焦虑组(P<0.05)。青少年首发GAD患者血清NPY、5-HT、BDNF水平与SLSI评分、CRP、IL-1α、IL-6、总延迟反应时间、无延迟反应时间呈负相关(P<0.05),与总延迟正确数、无延迟正确数呈正相关(P<0.05)。结论:青少年首发GAD患者随着焦虑程度加重,其生活应激强度增强、炎症因子水平升高,记忆功能减弱,且均与患者血清NPY、5-HT、BDNF水平降低有关。Objective:To investigate the changes of serum neuropeptide Y(NPY),5-hydroxytryptophan(5-HT)and brain-derived neurotrophic factor(BDNF)in first-episode generalized anxiety disorder(GAD)of adolescents with different anxiety levels and their corelation with life stress,inflammatory factors and memory function.Methods:147 adolescent first-episode GAD patients who were admitted to Chengdu mental health center from January 2019 to December 2021 were selected,and they were divided into mild anxiety group(5-9 scores,50 cases),moderate anxiety group(10-14 scores,65 cases)and severe anxiety group(15-21 scores,32 cases)according to the Generalized Anxiety Scale(GAD-7).Serum levels of NPY,5-HT,BDNF,C-reactive protein(CRP),interleukin(IL)-1αand IL-6 were detected.Students'Life Stress Inventory(SLSI)and delayed matching test(DMS)were used to evaluate the life stress level and memory function.The levels of serum NPY,5-HT,BDNF,CRP,IL-1αand IL-6 as well as SLSI and DMS were compared between groups,and the correlation between serum levels of serum NPY,5-HT and BDNF and levels of serum CRP,IL-lαand IL-6 as well as SLSI and DMS were analyzed.Results:The levels of serum NPY,5-HT and BDNF in severe anxiety group were lower than those in moderate anxiety group and mild anxiety group(P<0.05),and the moderate anxiety group was lower than the mild anxiety group(P<0.05).The levels of CRP,IL-lαand IL-6 and SLSI score in severe anxiety group were higher than those in moderate anxiety group and mild anxiety group(P<0.05).The moderate anxiety group was higher than the mild anxiety group(P<0.05).The total delayed response time and no delayed response time in the severe anxiety group were longer than those in the moderate anxiety group and the mild anxiety group(P<0.05),and the moderate anxiety group was longer than the mild anxiety group(P<0.05).The total delayed correct number and no delayed correct number in severe anxiety group were less than those in moderate anxiety group and mild anxiety group(P<0.05),and the moderate anxiety group wa

关 键 词：青少年 广泛性焦虑障碍 生活应激 炎症因子 记忆功能 神经肽Y 5-羟色胺 脑源性神经营养因子 

分 类 号：R749.72[医药卫生—神经病学与精神病学]