载脂蛋白E基因型与阿尔茨海默病锥体外系症状的相关性研究  

Association between Apolipoprotein E with extrapyramidal symptoms in Alzheimer’s disease

作　　者：吉晨晖 高超 王刚[1] 任汝静[1] Chenhui JI;Chao GAO;Gang WANG;Rujing REN(Department of Neurology,Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai,200025)

机构地区：[1]上海交通大学医学院附属瑞金医院神经内科,上海200025

出　　处：《阿尔茨海默病及相关病杂志》2023年第1期55-59,共5页Chinese Journal of Alzheimer's Disease and Related Disorders

基　　金：上海市医苑新星杰出青年医师计划项目(2019-72)。

摘　　要：目的:锥体外系症状(EPS)在阿尔茨海默病(AD)中并不少见。载脂蛋白E(APOE)ε4等位基因是迟发性AD的主要危险因素,既往国外研究有报告其与AD的EPS有关,本研究旨在探讨阿尔茨海默病患者载脂蛋白E基因型与AD是否合并EPS的关系。方法:纳入瑞金医院记忆门诊2012~2022年间130例临床诊断AD患者,男女比例为0.78:1,平均年龄70.51±11.65岁。回顾分析APOE基因型及有无合并锥体外系症状以确定APOE基因型与EPS的关系。结果:所有患者中,26例患者(20.00%)合并有EPS,其中多在AD发病的2年以后出现EPS症状(64.71%)。合并有EPS的患者(n=18)APOE基因型分布:ε3/ε3、ε2/ε3、ε3/ε4、ε2/ε4、ε4/ε4型分别为61.11%、5.56%、22.22%、5.56%、5.56%。调整年龄、性别、基线临床痴呆评级后,携带APOE ε4等位基因的AD患者与EPS合并症状的发生无相关性(OR:0.658,P=0.474)。结论:本研究表明APOE ε4等位基因与AD患者的EPS发生无明显相关性。Objective:Extrapyramidal symptoms(EPS)are not uncommon in Alzheimer's disease(AD).As apolipoprotein E(APOE)ε4 allele is a major risk factor for late-onset AD,which has been reported to be related to EPS of AD in previous research.This study aims to assess the association between APOE genotype and the development of EPS in AD.Methods:This study recruited 130 clinically diagnosed AD patients aged 70.51±11.65 years from 2012 to 2022 in the Memory Clinic of Ruijin Hospital.The ratio of male and female was 0.78:1.We reviewed the medical charts to determine the development of EPS and APOE genotypes were also confirmed,aiming to reveal the relationship between them.Results:Among these patients,26 AD patients(20.00%)be found with EPS,and most EPS occured two years after AD(64.71%).The APOE genotypes were examined in AD patients with EPS(n=18).The percentages ofε3/ε3、ε2/ε3、ε3/ε4、ε2/ε4、ε4/ε4 were 61.11%、5.56%、22.22%、5.56%、5.56%,respectively.After adjusting the age,sex,baseline clinical dementia rating,we found AD patients carrying APOEε4 allele was not related to develop EPS(OR:0.658,P=0.474).Conclusion:This study shows that APOEε4 allele has no correlation with EPS in AD patients.

关 键 词：阿尔茨海默病 锥体外系症状 APOE 

分 类 号：R749.16[医药卫生—神经病学与精神病学]