苦丁茶(粗壮女贞)成分结构特征、活性作用机制及质量控制研究进展  

Kudingcha(Ligustrum robustum(Roxb.) Blume):Structural Characteristics of Constituents,Bioactivities and Action Mechanisms,and Quality Control

作　　者：凌志洲 曾荣[2] 范倩 吴润松 李振雨 陈向东 孙冬梅 罗文汇 LING Zhizhou;ZENG Rong;FAN Qian;WU Runsong;LI Zhenyu;CHEN Xiangdong;SUN Dongmei;LUO Wenhui(Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Formula,Guangdong Yifang Pharmaceutical Co.Ltd.,Foshan 528244,China;School of Food Science and Engineering,Foshan University,Foshan 528231,China;School of Pharmaceutical Sciences,Guangzhou University of Chinese Medicine,Guangzhou 510405,China)

机构地区：[1]广东一方制药有限公司,广东省中药配方颗粒企业重点实验室,广东佛山528244 [2]佛山科学技术学院食品科学与工程学院,广东佛山528231 [3]广州中医药大学中药学院,广东广州510405

出　　处：《食品科学》2023年第7期394-403,共10页Food Science

基　　金：广东省重点领域研发计划项目(2020B1111110007,2019B110209005)。

摘　　要：苦丁茶(粗壮女贞)是一种应用广泛和极具经济价值的传统药食同源植物,在我国贵州省、云南省和四川省等地区作为民族药和代茶饮料使用历史悠久,近年来备受关注。其化学成分复杂,已从中分离得到苯丙素、苯乙醇、单萜、环烯醚萜、黄酮及挥发油等成分;药理作用广泛,具有降脂、抗氧化、抗病毒、抗菌、抗炎、免疫调节和抗癌等活性作用。但近几年针对粗壮女贞基原的苦丁茶综述报道较少,仅在女贞属植物或苦丁茶大类的研究进展中稍作提及,不利于苦丁茶(粗壮女贞)的规范化研究和开发利用。本文较为全面地对近年来国内外关于苦丁茶(粗壮女贞)的成分基础、药理活性及其质量控制现状研究进行归纳总结,并重点分析其特征性成分的结构基础特征和药理活性机制,为苦丁茶(粗壮女贞)后续的特征性成分的制备分离、结构鉴定和药理活性机制研究提供理论参考。Kudingcha(Ligustrum robustum(Roxb.) Blume) is widely used as a traditional medicinal and culinary plant of great economic value.It has a long history of use as an ethnic medicine and an alternative to tea in Guizhou,Yunnan and Sichuan provinces of China,and has attracted much attention in recent years.The chemical composition of kudingcha(Ligustrum robustum(Roxb.) Blume) is complex,from which phenylpropanoids,phenylethanoids,monoterpenes,iridoids,flavonoids and volatile oils have been isolated.It has a wide range of pharmacological effects,including lipid-lowering,antioxidant,antiviral,antibacterial,anti-inflammatory,immune regulatory and anticancer activities.However,in recent years,there are few systematic reviews on Ligustrum robustum(Roxb.) Blume,even though it is only mentioned in the reviews on Ligustrum plants or kudingcha,which is not conducive to the standardized research,development and utilization of kudingcha(Ligustrum robustum(Roxb.) Blume).This paper comprehensively summarizes recent research on the composition,pharmacological activity and quality control of kudingcha(Ligustrum robustum(Roxb.) Blume)with focuses on the structural features and pharmacological mechanism of its characteristic components.This paper will provide a theoretical reference for the preparation,separation,structure identification and pharmacological research of the characteristic components of kudingcha(Ligustrum robustum(Roxb.) Blume).

关 键 词：苦丁茶 粗壮女贞 结构特征 药效活性 作用机制 质量控制 

分 类 号：TS272.5[农业科学—茶叶生产加工] TS272.7[轻工技术与工程—农产品加工及贮藏工程]