自然杀伤细胞在肿瘤增殖和转移中的研究进展  

Research Progress of Natural Killer Cells in Tumor Proliferation and Metastasis

作　　者：马聪 朱虹 赵慧昂 Ma Cong;Zhu Hong;Wang Hui’ang(Xi’an Siyuan University,Xi’an 710038,China)

机构地区：[1]西安思源学院,西安710038

出　　处：《黑龙江科学》2023年第6期102-104,共3页Heilongjiang Science

摘　　要：自然杀伤细胞主要通过识别肿瘤细胞表面的分子来发挥细胞的毒性作用,同时还可以产生多种细胞因子协同参与免疫反应。鉴于自然杀伤细胞在杀伤肿瘤细胞过程中的巨大潜力,目前已有一些靶向自然杀伤细胞的治疗方案,但主要集中在极少的癌种中,大多数实体瘤患者的疗效还有待提升。对自然杀伤细胞在肿瘤增殖和转移过程中涉及的生物学过程和相关机制进行概述,旨在为相关肿瘤的免疫疗法和治疗药物的开发提供科学参考。Natural killer cells mainly play the toxic effect through recognizing the molecules on the surface of tumor cells,and produce a variety of cytokines synergistically involving in the immune response.In view of the great potential of natural killer cells in the process of killing tumor cells,there are currently some therapies targeting natural killer cells,but they are mainly concentrated in very few cancer species.The efficacy of most patients with solid tumors needs to be improved.The study summarizes the biological processes and related mechanisms of natural killer cells in the process of tumor proliferation and metastasis,to provide scientific reference for the development of related tumor immunization therapy and therapeutic medicine.

关 键 词：自然杀伤细胞 肿瘤增殖和转移 免疫逃逸 细胞识别 细胞毒性 

分 类 号：R730.5[医药卫生—肿瘤]