Microenvironment-responsive electrocution of tumor and bacteria by implants modified with degenerate semiconductor film  

作　　者：Donghui Wang Shun Xing Feng Peng Xianming Zhang Ji Tan Xueqing Hao Yuqin Qiao Naijian Ge Xuanyong Liu 

机构地区：[1]State Key Laboratory of High Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai,200050,China [2]School of Health Sciences and Biomedical Engineering,Hebei University of Technology,Tianjin,300130,China [3]Department of Orthopedics,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou,Guangdong,510080,China [4]Intervention Center,Eastern Hepatobiliary Surgery Hospital,The Third Affiliated Hospital of Naval Medical University,Shanghai,200438,China [5]Center of Materials Science and Optoelectronics Engineering,University of Chinese Academy of Sciences,Beijing,100049,China [6]School of Chemistry and Materials Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,1 Sub-lane Xiangshan,Hangzhou,310024,China

出　　处：《Bioactive Materials》2023年第2期472-488,共17页生物活性材料（英文）

基　　金：support from the National Key R&D Program of China(2021YFC2400500);National Natural Science Foundation of China(31971249,51901239);Science and Technology Commission of Shanghai Municipality(19JC1415500,20S31903300);Natural Science Foundation of Hebei Province of China(E2021202001);High-level full-time talents project of Guangdong Provincial People’s Hospital(KY012021462).

摘　　要：Implantable biomaterials are widely used in the curative resection and palliative treatment of various types of cancers.However,cancer residue around the implants usually leads to treatment failure with cancer reoccurrence.Postoperation chemotherapy and radiation therapy are widely applied to clear the residual cancer cells but induce serious side effects.It is urgent to develop advanced therapy to minimize systemic toxicity while maintaining efficient cancer-killing ability.Herein,we report a degenerate layered double hydroxide(LDH)film modified implant,which realizes microenvironment-responsive electrotherapy.The film can gradually transform into a nondegenerate state and release holes.When in contact with tumor cells or bacteria,the film quickly transforms into a nondegenerate state and releases holes at a high rate,rendering the“electrocution”of tumor cells and bacteria.However,when placed in normal tissue,the hole release rate of the film is much slower,thus,causing little harm to normal cells.Therefore,the constructed film can intelligently identify and meet the physiological requirements promptly.In addition,the transformation between degenerate and nondegenerate states of LDH films can be cycled by electrical charging,so their selective and dynamic physiological functions can be artificially adjusted according to demand.

关 键 词：ELECTROTHERAPY Implant Layered double hydroxides ANTI-TUMOR ANTIBIOSIS 

分 类 号：R730[医药卫生—肿瘤]