The role of cholesterol in modifying the lipid-lowering effects of Fuzhuan brick-tea in Caenorhabditis elegans via SBP-1/SREBP  

作　　者：Lianyun Pan Yan Lu Shen Dai Xiangyue Tang Ligui Xiong Zhonghua Liu Yushun Gong 

机构地区：[1]National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals,Hunan Agricultural University,Changsha 410128,China [2]Yunnan Key Laboratory of Tea Science,Tea Research Institute of Yunnan Academy of Agricultural Sciences,Menghai 666200,China [3]Key Laboratory of Tea Science of Ministry of Education,Hunan Agricultural University,Changsha,410128,China

出　　处：《Food Science and Human Wellness》2023年第6期2297-2305,共9页食品科学与人类健康（英文）

基　　金：supported by the National Natural Science Foundation of China(31801547);Some C.elegans strains were provided by CGC,which is funded by the NIH Office of Research Infrastructure Programs.

摘　　要：Fuzhuan brick-tea(FZT)has long been consumed for its supposed weight loss and lipid-lowering benefi ts.In this study,we show that the regulation of fat storage in Caenorhabditis elegans from a water extract of FZT was affected by cholesterol levels.We found that FZT signifi cantly decreased fat storage under normal cholesterol levels or in a cholesterol-free diet,while lipid accumulation was increased for a high cholesterol diet.Moreover,this mechanism may involve the conserved sterol regulatory element-binding protein(SREBP)/mediator-15(MDT-15)signaling pathway and the nuclear hormone receptor NHR-80.In addition,lipid synthesis-related genes inhibited by FZT were partially affected by a cholesterol-free diet.Thus,our fi ndings suggested that the potential lipid-lowering effects of FZT may depend on the cholesterol level,which may help to improve the consumption of FZT.

关 键 词：Fuzhuan brick tea CHOLESTEROL Fat storage Sterol regulatory element-binding protein 

分 类 号：TS272.54[农业科学—茶叶生产加工]