A bioinspired and high-strengthed hydrogel for regeneration of perforated temporomandibular joint disc:Construction and pleiotropic immunomodulatory effects  

作　　者：Xiao Xu Baiyan Sui Xin Liu Jiao Sun 

机构地区：[1]Department of Dental Materials,Shanghai Biomaterials Research&Testing Center,Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine,College of Stomatology,Shanghai Jiao Tong University,National Center for Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology,Shanghai,200011,PR China

出　　处：《Bioactive Materials》2023年第7期701-715,共15页生物活性材料（英文）

基　　金：This work was sponsored by grants from the National Nature Science Foundation of China(82072070);the National Key Research and Development Program of China(2018YFC1105202);Science and Technology Commission of Shanghai Municipality(21DZ2291700,18DZ2290300).

摘　　要：Due to the lack of an ideal material for TMJ(temporomandibular joint)disc perforation and local inflammation interfering with tissue regeneration,a functional TGI/HA-CS(tilapia type I gelatin/hyaluronic acid-chondroitin sulfate)double network hydrogel was constructed in this paper.It was not only multiply bionic in its composition,structure and mechanical strength,but also endowed with the ability to immunomodulate microenvironment and simultaneously induce in situ repair of defected TMJ discs.On the one hand,it inhibited inflammatory effects of inflammasome in macrophages,reduced the extracellular matrix(ECM)-degrading enzymes secreted by chondrocytes,reversed the local inflammatory state,promoted the proliferation of TMJ disc cells and induced fibrochondrogenic differentiation of synovium-derived mesenchymal stem cells(SMSCs).On the other hand,it gave an impetus to repairing a relatively-large(6 mm-sized)defect in mini pigs’TMJ discs in a rapid and high-quality manner,which suggested a promising clinical application.

关 键 词：Bioinspired double network hydrogel TMJ disc Perforation Inflammasome IMMUNOMODULATION Induced regeneration 

分 类 号：TQ427.26[化学工程] R782.6[医药卫生—口腔医学]