Bone/cartilage targeted hydrogel: Strategies and applications  

作　　者：Hao Zhang Shunli Wu Weikai Chen Yan Hu Zhen Geng Jiacan Su 

机构地区：[1]Institute of Translational Medicine,Shanghai University,Shanghai,200444,China [2]Musculoskeletal Organoid Research Center,Shanghai University,Shanghai,200444,China [3]School of Medicine,Shanghai University,Shanghai,200444,China [4]School of Environmental and Chemical Engineering,Shanghai University,Shanghai,200444,China

出　　处：《Bioactive Materials》2023年第5期156-169,共14页生物活性材料（英文）

基　　金：This work was funded by the National Key R&D Program of China(2018YFC2001500);Key Project of The National Natural Science Foundation of China(82230071);National Natural Science Foundation of China(82172098,32101084).

摘　　要：The skeletal system is responsible for weight-bearing,organ protection,and movement.Bone diseases caused by trauma,infection,and aging can seriously affect a patient’s quality of life.Bone targeted biomaterials are suitable for the treatment of bone diseases.Biomaterials with bone-targeted properties can improve drug utilization and reduce side effects.A large number of bone-targeted micro-nano materials have been developed.However,only a few studies addressed bone-targeted hydrogel.The large size of hydrogel makes it difficult to achieve systematic targeting.However,local targeted hydrogel still has significant prospects.Molecules in bone/cartilage extracellular matrix and bone cells provide binding sites for bone-targeted hydrogel.Drug delivery systems featuring microgels with targeting properties is a key construction strategy for bone-targeted hydrogel.Besides,injectable hydrogel drug depot carrying bone-targeted drugs is another strategy.In this review,we summarize the bone-targeted hydrogel through application environment,construction strategies and disease applications.We hope this article will provide a reference for the development of bone-targeted hydrogels.We also hope this article could increase awareness of bone-targeted materials.

关 键 词：BONE CARTILAGE HYDROGEL Target therapy Bone disease 

分 类 号：R738.1[医药卫生—肿瘤] TQ427.26[医药卫生—临床医学]