Tissue adhesive hemostatic microneedle arrays for rapid hemorrhage treatment  

作　　者：Reihaneh Haghniaz Han-Jun Kim Hossein Montazerian Avijit Baidya Maryam Tavafoghi Yi Chen Yangzhi Zhu Solmaz Karamikamkar Amir Sheikhi Ali Khademhosseini 

机构地区：[1]Department of Bioengineering,University of California,Los Angeles,410 Westwood Plaza,Los Angeles,CA,90095,United States [2]California NanoSystems Institute,University of California,Los Angeles,570 Westwood Plaza,Los Angeles,CA,90095,United States [3]Terasaki Institute for Biomedical Innovation,11570 W Olympic Boulevard,Los Angeles,CA,90024,United States [4]Department of Chemical Engineering,The Pennsylvania State University,University Park,PA,16802,United States [5]Department of Biomedical Engineering,The Pennsylvania State University,University Park,PA,16802,United States

出　　处：《Bioactive Materials》2023年第5期314-327,共14页生物活性材料（英文）

基　　金：A.S.would like to acknowledge the financial support from the Canadian Institutes of Health Research(CIHR)through a postdoctoral fellowship as well as the startup fund from The Pennsylvania State University;A.K.would like to acknowledge funding from the National Institutes of Health(1R01EB023052,1R01HL140618,CA257558,DK130566).We acknowledge UCLA CFAR grant 5P30 AI028697 and the UCLA AIDS Institute.The authors thank Profs.S.Li and M.Butte at UCLA for providing cryo-sectioning equipment and lab space for the blood coagulation tests,respectively.The authors also thank Prof.K.J.Lee for his advice on microneedle fabrication.

摘　　要：Blood loss by hemorrhaging wounds accounts for over one-third of~5 million trauma fatalities worldwide every year.If not controlled in a timely manner,exsanguination can take lives within a few minutes.Developing new biomaterials that are easy to use by non-expert patients and promote rapid blood coagulation is an unmet medical need.Here,biocompatible,and biodegradable microneedle arrays(MNAs)based on gelatin methacryloyl(GelMA)biomaterial hybridized with silicate nanoplatelets(SNs)are developed for hemorrhage control.The SNs render the MNAs hemostatic,while the needle-shaped structure increases the contact area with blood,synergistically accelerating the clotting time from 11.5 min to 1.3 min in vitro.The engineered MNAs reduce bleeding by~92%compared with the untreated injury group in a rat liver bleeding model.SN-containing MNAs outperform the hemostatic effect of needle-free patches and a commercial hemostat in vivo via combining micro-and nanoengineered features.Furthermore,the tissue adhesive properties and mechanical interlocking support the suitability of MNAs for wound closure applications.These hemostatic MNAs may enable rapid hemorrhage control,particularly for patients in developing countries or remote areas with limited or no immediate access to hospitals.

关 键 词：HEMOSTAT MICRONEEDLES HEMORRHAGE Bleeding Gelatin methacryloyl Silicate nanoplatelets 

分 类 号：R318.08[医药卫生—生物医学工程]