Retinoprotective compounds,current efficacy,and future prospective  

作　　者：Rachele Marino Rebecca Sappington Marco Feligioni 

机构地区：[1]Laboratory of Neuronal Cell Signaling,EBRI Rita Levi-Montalcini Foundation,Rome,Italy [2]Department of Neurobiology and Anatomy,Wake Forest School of Medicine,Atrium Health Wake Forest Baptist Medical Center,Winston-Salem,NC,USA [3]Department of Ophthalmology,Wake Forest School of Medicine,Winston-Salem,NC,USA [4]Department of Neurorehabilitation Sciences,Casa di Cura Igea,Milan,Italy

出　　处：《Neural Regeneration Research》2023年第12期2619-2622,共4页中国神经再生研究（英文版）

基　　金：partially supported by Bright Focus Glaucoma grant No. G2022015S (to MF)

摘　　要：Retinal dysfunction is the most common cause of vision loss in several retinal disorders.It has been estimated a great increase in these pathologies that are becoming more globally widespread and numerous over time,also supported by the life expectancy increment.Among different types of retinopathies,we can account some that share causes,symptoms,and treatment including diabetic retinopathy,age-related macular degeneration,glaucoma,and retinitis pigmentosa.Molecular changes,environmental factors,and genetic predisposition might be some of the main causes that drive retinal tissue to chronic inflammation and neurodegeneration in these retinopathies.The treatments available on the market contain compounds that efficiently ameliorate some of the important clinical features of these pathologies like stabilization of the intraocular pressure,reduction of eye inflammation,control of eye oxidative stress which are considered the major molecular mechanisms related to retinal dysfunction.Indeed,the most commonly used drugs are antiinflammatories,such as corticosteroids,antioxidant,hypotonic molecules and natural neuroprotective compounds.Unfortunately,these drugs,which are fundamental to treating disease symptoms,are not capable to cure the pathologies and so they are not life-changing for patients.This review provided an overview of current treatments on the market,but more interestingly,wants to be a quick window on the new treatments that are now in clinical trials.Additionally,it has been here highlighted that the recent technical enhancement of the investigation methods to identify the various retinopathies causes might be used as a sort of“precise medicine”approach to tailor the identification of molecular pathways involved and potentially study a dedicated treatment for each patient.This approach includes the use of cutting-edge technologies like gene therapy and metabolomics.

关 键 词：age-related macular degeneration anti-inflammatory drugs ANTIOXIDANTS diabetic retinopathy GLAUCOMA neuroprotective compounds retinitis pigmentosa retinopathies vision loss 

分 类 号：R774.1[医药卫生—眼科]