Molecular chaperones in stroke-induced immunosuppression  

作　　者：Haoduo Qiao Qing Xu Yunfei Xu Yao Zhao Nina He Jie Tang Jie Zhao Ying Liu 

机构地区：[1]Department of Neurosurgery,Xiangya Hospital,Central South University,Changsha,Hunan Province,China [2]Department of Pathophysiology,Xiangya School of Medicine,Central South University,Changsha,Hunan Province,China [3]Sepsis Translational Medicine Key Laboratory of Hunan Province,Changsha,Hunan Province,China [4]National Medicine Functional Experimental Teaching Center,Changsha,Hunan Province,China [5]Department of Clinical Pharmacology,Xiangya Hospital,Central South University,Changsha,Hunan Province,China

出　　处：《Neural Regeneration Research》2023年第12期2638-2644,共7页中国神经再生研究（英文版）

基　　金：the National Natural Science Foundation of China,Nos.82172147(to YL),81571880(to YL),81373147(to YL),30901555(to JZ),30972870(to YL);the Natural Science Foundation of Hunan Province,Nos.2021JJ30900,2016JJ2157(both to YL)。

摘　　要：Stroke-induced immunosuppression is a process that leads to peripheral suppression of the immune system after a stroke and belongs to the central nervous system injury-induced immunosuppressive syndrome.Stroke-induced immunosuppression leads to increased susceptibility to post-stroke infections,such as urinary tract infections and stroke-associated pneumonia,worsening prognosis.Molecular chaperones are a large class of proteins that are able to maintain proteostasis by directing the folding of nascent polypeptide chains,refolding misfolded proteins,and targeting misfolded proteins for degradation.Various molecular chaperones have been shown to play roles in stroke-induced immunosuppression by modulating the activity of other molecular chaperones,cochaperones,and their associated pathways.This review summarizes the role of molecular chaperones in stroke-induced immunosuppression and discusses new approaches to restore host immune defense after stroke.

关 键 词：Hsp70 HSP72 HSP90 HspB5 hypothalamic-pituitary-adrenal axis molecular chaperones NEUROPROTECTION STROKE stroke-induced immunosuppression sympathetic nervous system 

分 类 号：R743.3[医药卫生—神经病学与精神病学]