天然产物来源的抗SARS-CoV-2药物研究进展  

Recent progress of anti-SARS-CoV-2 agents derived from natural products

作　　者：杨娩玲 宋乐天 叶冰 程玉森 高升华 刘新泳[1] 展鹏[1] YANG Mian-ling;SONG Le-tian;YE Bing;CHENG Yu-sen;GAO Sheng-hua;LIU Xin-yong;ZHAN Peng(Department of Medicinal Chemistry,Key laboratory of Chemical Biology(Ministry of Education),School of Pharmaceutical Sciences,Shandong University,Jinan 250012,China)

机构地区：[1]山东大学药学院药物化学研究所/化学生物学教育部重点实验室,山东济南250012

出　　处：《中国药物化学杂志》2023年第3期191-216,共26页Chinese Journal of Medicinal Chemistry

基　　金：山东省杰出青年基金项目(ZR2020JQ31);中国博士后科学基金面上基金项目(2021M702003);广东省基础与应用基础研究基金区域联合基金青年基金项目(2021A1515110740)。

摘　　要：广谱高效的小分子药物是应对新型冠状病毒感染(COVID-19)及未来可能爆发疫情的重要武器。天然产物是药物先导化合物的重要来源,在抗COVID-19的药物研发中得到了广泛关注。本文综述了抗新型冠状病毒(SARS-CoV-2)药物的关键靶点和具有抗SARS-CoV-2活性的天然产物的研究进展,以期为抗SARS-CoV-2药物的研发提供参考。The broad-spectrum small molecule antiviral drugs are important weapons to deal with COVID-19 and possible future outbreaks.Natural products are significant sources of lead compounds for drugs,and have received extensive attention in the development of drugs against COVID-19.In this paper the key targets of anti-SARS-CoV-2 drugs and the research progress of natural products with anti-SARS-CoV-2 activity were reviewed,in order to provide insights into the development of anti-SARS-CoV-2 drugs.

关 键 词：新型冠状病毒 新型冠状病毒感染 天然产物 抑制剂 药物发现 

分 类 号：R914[医药卫生—药物化学]