Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats  

作　　者：Gayatri Khuntia Jeevan Ranjan Dash Biswadeep Jena Uma Kanta Mishra Subash Chandra Parija 

机构地区：[1]Department of Pharmacology and Toxicology,College of Veterinary Sciences and Animal Husbandry,OUAT,Bhubaneswar,India [2]Department of Veterinary Surgery and Radiology,College of Veterinary Sciences and Animal Husbandry,OUAT,Bhubaneswar,India [3]Department of Veterinary Anatomy and Histology,College of Veterinary Sciences and Animal Husbandry,OUAT,Bhubaneswar,India

出　　处：《Asian Pacific Journal of Tropical Biomedicine》2023年第4期156-164,共9页亚太热带生物医学杂志（英文版）

摘　　要：Objective:To explore the cardioprotective effect of hesperidin against arsenic trioxide-induced cardiac toxicity in rats.Methods:Cardiac toxicity was induced by oral administration of 4 mg/kg arsenic trioxide for 30 days.Hematological,biochemical,electrocardiography,echocardiography,and histopathological examinations were performed.Results:Hesperidin decreased the neutrophil-to-lymphocyte ratio,calcium,creatine kinase-myoglobin binding,lactate dehydrogenase,IL-6,and lipid peroxidation,as well as increased sodium and potassium concentration and superoxide dismutase and catalase activity in arsenic trioxide-intoxicated rats.Moreover,it reduced peak systolic velocity and end-diastolic velocity while increasing heart rate.Arsenic trioxide-induced histopathological damage to cardiac tissue was prominently alleviated by hesperidin treatment.Conclusions:Hesperidin attenuates arsenic trioxide-induced cardiac toxicity in rats.Therefore,it can be further explored as a cardioprotective agent.

关 键 词：Arsenic trioxide HESPERIDIN CARDIOTOXICITY ECG CK-MB LDH 

分 类 号：R285.5[医药卫生—中药学]