Multidrug dissolvable microneedle patch for the treatment of recurrent oral ulcer  

作　　者：Yuqiong Wang An’an Sheng Xinran Jiang Shanshan Yang Long Lin Mingzhu Yang Fengshuo Zhu Yongyan Hu Jian Li Lingqian Chang 

机构地区：[1]Beijing Advanced Innovation Center for Biomedical Engineering,School of Biological Science and Medical Engineering,Beihang University,Beijing 100191,China [2]Department of Stomatology,Xiang’an Hospital of Xiamen University,Xiamen 361000,China [3]Institute of Plastic Machinery and Plastic Engineering,School of Mechanical and Electrical Engineering,Beijing University of Chemical Technology,Beijing 100029,China [4]Department of Biochemistry,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences(CAMS)and Peking Union Medical College,Beijing 100005,China [5]Department of Oral Maxillofacial-Head and Neck Oncology,Shanghai Ninth People’s Hospital,Shanghai 200011,China [6]Laboratory Animal Facility,Peking University First Hospital,Beijing 100034,China

出　　处：《Bio-Design and Manufacturing》2023年第3期255-267,共13页生物设计与制造（英文）

基　　金：the National Natural Science Foundation of China(Nos.62003023,32071407,52073138,52003018 and 52003019);Beijing Natural Science Foundation(No.7212204);Beijing Advanced Innovation Center for Biomedical Engineering and Beihang University.

摘　　要：Recurrent oral ulcer is a painful oral mucosal disorder that affects 20%of the world’s population.The lack of a radical cure due to its unknown underlying cause calls for innovative symptomatic treatments.This work reports a hyaluronic acid-based dissolvablemicroneedle patch(ROUMNpatch,short for recurrent oral ulcer microneedle)loaded with dexamethasone acetate,vitamin C and tetracaine hydrochloride for the treatment of recurrent oral ulcers.The ROUMN patch shows enhancement in both the anti-inflammatory effect elicited by dexamethasone and the pro-proliferation effect of vitamin C.In vitro experiments show that ROUMN has a higher efficiency in suppressing lipopolysaccharide(LPS)-induced interleukin-6(IL-6)expression than dexamethasone alone.Cell proliferation and migrationwere also significantly promoted byROUMNcompared to vitamin C alone.The healing-promoting effect of ROUMN was also verified in vivo using an acetic acid-cauterized oral ulcer model in rats.ROUMN as a treatment accelerated the healing process of oral ulcers,shortening the total healing time to 5 days compared with the 7 days required by treatment using watermelon frost,a commonly used over-the-counter(OTC)drug for oral ulcers.The rapid dissolution of the hyaluronic acid-based microneedles and the superior healing-promoting effect of the drug combination could lead to a broad application prospect of the ROUMN patch in the treatment of recurrent oral ulcers.

关 键 词：Recurrent oral ulcer Dissolvable microneedle Hyaluronic acid microneedle MULTIDRUG ANTI-INFLAMMATION Healing promoting effect 

分 类 号：R781.5[医药卫生—口腔医学]