SPINOPHILIN: A multiplayer tumor suppressor  

作　　者：Eva M.Verdugo-Sivianes Amancio Carnero 

机构地区：[1]Instituto de Biomedicina de Sevilla,IBIS,Hospital Universitario Virgen del Rocio,Consejo Superior de Investigaciones Cientificas,Universidad de Sevilla,Seville 41013,Spain [2]CIBERONC,Instituto de Salud Carlos Il,Madrid 28029,Spain

出　　处：《Genes & Diseases》2023年第1期187-198,共12页基因与疾病（英文）

基　　金：This work was supported by Ministerio de Ciencia,Innovacion y Universidades(MCIU),Plan Estatal de I+D+I 2018,Spain,Agencia Estatal de Investigacion(AEl),Spain,and Regional Development European Funds(FEDER),European Union(No.RTI2018-097455-B-I00 and RED2018-102723);CIBER of Cancer,Spain(No.CB16/12/00275);Consejeria de Salud of the Junta de Andalucia,Spain(No.Pl-0397-2017);Consejeria of Economia,Conocimiento,Empresas y Universidad of the Junta de Andalucia,Spain(No.P18-RT-2501);Fundacion AECC,Spain and Fundacion Eugenio Rodriguez Pascual,Spain.EMV-S was funded by a postdoctoral contract from Consejeria of Transformacion Economica,Industria,Conocimiento,y Universidades of the JuntadeAndalucia,Spain(No.CTEICU/PAIDI2020).

摘　　要：SPINOPHILIN(SPN,PPP1R9B or NEURABIN-2)is a multifunctional protein that regulates protein-protein interactions in different cell signaling pathways.SPN is also one of the regulatory subunits of protein phosphatase 1(PP1),implicated in the dephosphorylation of retinoblastoma protein(pRB)during cell cycle.The SPN gene has been described as a tumor suppressor in different human tumor contexts,in which low levels of SPN are correlated with a higher grade and worse prognosis.In addition,mutations of the SPN protein have been reported in human tumors.Recently,an oncogenic mutation of sPN,A566V,was described,which affects both the SPN-PP1 interaction and the phosphatase activity of the holoenzyme,and promotes p53-dependent tumorigenesis by increasing the cancer stem cell(CsC)pool in breast tumors.Thus,the loss or mutation of SPN could be late events that promotes tumor progression by increasing the CSC pool and,eventually,the malignant behavior of the tumor.

关 键 词：Cancer therapy Phosphatase PP1 SPINOPHILIN Tumor suppressor TUMORIGENESIS 

分 类 号：R730.5[医药卫生—肿瘤]