Aerobic glycolysis promotes tumor immune evasion and tumor cell stemness through the noncanonical function of hexokinase 2  

作　　者：Haiyan He Liwei Xiao Juhong Wang Dong Guo Zhimin Lu 

机构地区：[1]Department of Pharmacy,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou,Zhejiang,P.R.China [2]Zhejiang Provincial Key Laboratory of Pancreatic Disease,the First Affiliated Hospital,and Institute of Translational Medicine,Zhejiang University School of Medicine,Zhejiang University,Hangzhou,Zhejiang,P.R.China [3]Cancer Center,Zhejiang University,Hangzhou,Zhejiang,P.R.China [4]Department of Thoracic Surgery,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,P.R.China [5]State Key Laboratory of Molecular Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,P.R.China

出　　处：《Cancer Communications》2023年第3期387-390,共4页癌症通讯（英文）

基　　金：Ministry of Science and Technology of the People’s Republic of China,Grant/Award Number:2020YFA0803300;National Natural Science Foundation of China,Grant/Award Numbers:82188102,82030074,81902423;Zhejiang Natural Science Foundation Key Project,Grant/Award Number:LD21H160003;Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang,Grant/Award Number:2019R01001。

摘　　要：The Warburg effect is a key metabolic feature of cancer cells and manifests as substantially increased glycolysis regardless of the presence of oxygen[1].The initial step of glycolysis is catalyzed by hexokinase(HK),which converts glucose to the metabolic intermediate glucose-6-phosphate(G-6-P).Four kinds of HK isozymes,HK1,HK2,HK3 and HK4,have been found in mammals.HK1 and HK2 bind to the mitochondrial outer membrane through interac-tions with voltage-dependent anion channels(VDACs),and both of thesemolecules have a high affinity for glucose[2].HK2 overexpression is frequently detected in cancer cells,leading to enhanced aerobic glycolysis and tumorigenesis that renders HK2 an attractive target for cancer treatment[3].Important advances in research on cancer metabolism in recent decades have revealed thatmetabolic enzymes have non-metabolic functions,which play pivotal roles in tumor development and progression[4–6].Recent studies uncovered that HK2 directly promoted tumor immune evasion through the activity of a previously unidentified protein kinase and tumor cell stemness via upregulation of CD133 expression.

关 键 词：GLYCOLYSIS METABOLISM ATTRACTIVE 

分 类 号：R730.3[医药卫生—肿瘤]