Current and emerging therapeutic approaches for colorectal cancer:A comprehensive review  

作　　者：Anil Kumar Vipasha Gautam Arushi Sandhu Kajal Rawat Antika Sharma Lekha Saha 

机构地区：[1]Department of Pharmacology,Post Graduate Institute of Medical Education and Research,Chandigarh 160012,India

出　　处：《World Journal of Gastrointestinal Surgery》2023年第4期495-519,共25页世界胃肠外科杂志（英文版）（电子版）

摘　　要：Colorectal cancer(CRC)affects 1 in 23 males and 1 in 25 females,making it the third most common cancer.With roughly 608000 deaths worldwide,CRC accounts for 8%of all cancer-related deaths,making it the second most common cause of death due to cancer.Standard and conventional CRC treatments include surgical expurgation for resectable CRC and radiotherapy,chemotherapy,immunotherapy,and their combinational regimen for non-resectable CRC.Despite these tactics,nearly half of patients develop incurable recurring CRC.Cancer cells resist the effects of chemotherapeutic drugs in a variety of ways,including drug inactivation,drug influx and efflux modifications,and ATPbinding cassette transporter overexpression.These constraints necessitate the development of new target-specific therapeutic strategies.Emerging therapeutic approaches,such as targeted immune boosting therapies,non-coding RNA-based therapies,probiotics,natural products,oncolytic viral therapies,and biomarkerdriven therapies,have shown promising results in preclinical and clinical studies.We tethered the entire evolutionary trends in the development of CRC treatments in this review and discussed the potential of new therapies and how they might be used in conjunction with conventional treatments as well as their advantages and drawbacks as future medicines.

关 键 词：Colorectal cancer CHEMOTHERAPY IMMUNOTHERAPY RNA interference PROBIOTICS Oncolytic viral therapy 

分 类 号：R735.34[医药卫生—肿瘤]