Morphological aspects of small-duct cholangiopathies:A minireview  

作　　者：Eva Sticova Ondrej Fabian 

机构地区：[1]Clinical and Transplant Pathology Centre,Institute for Clinical and Experimental Medicine,Prague 14021,Czech Republic [2]Department of Pathology,The Third Faculty of Medicine,Charles University and University Hospital Kralovske Vinohrady,Prague 10000,Czech Republic [3]Department of Pathology and Molecular Medicine,The Third faculty of Medicine,Charles University and Thomayer University Hospital,Prague 14059,Czech Republic

出　　处：《World Journal of Hepatology》2023年第4期538-553,共16页世界肝病学杂志（英文版）（电子版）

摘　　要：The biliary system consists of intrahepatic and extrahepatic bile ducts lined by biliary epithelial cells(cholangiocytes).Bile ducts and cholangiocytes are affected by a variety of disorders called cholangiopathies,which differ in aetiology,pathogenesis,and morphology.Classification of cholangiopathies is complex and reflects pathogenic mechanisms(immune-mediated,genetic,drug-and toxininduced,ischaemic,infectious,neoplastic),predominant morphological patterns of biliary injury(suppurative and non-suppurative cholangitis,cholangiopathy),and specific segments of the biliary tree affected by the disease process.While the involvement of large extrahepatic and intrahepatic bile ducts is typically visualised using radiology imaging,histopathological examination of liver tissue obtained by percutaneous liver biopsy still plays an important role in the diagnosis of cholangiopathies affecting the small intrahepatic bile ducts.To increase the diagnostic yield of a liver biopsy and determine the optimal therapeutic approach,the referring clinician is tasked with interpreting the results of histopathological examination.This requires knowledge and understanding of basic morphological patterns of hepatobiliary injury and an ability to correlate microscopic findings with results obtained by imaging and laboratory methods.This minireview describes the morphological aspects of small-duct cholangiopathies pertaining to the diagnostic process.

关 键 词：Bile duct CHOLANGIOCYTES CHOLANGIOPATHY CHOLANGITIS Liver biopsy HISTOPATHOLOGY 

分 类 号：R575.7[医药卫生—消化系统]