The bioelectrical properties of bone tissue  

作　　者：Boon Chin Heng Yunyang Bai Xiaochan Li Yanze Meng Yanhui Lu Xuehui Zhang Xuliang Deng 

机构地区：[1]Department of Dental Materials&Dental Medical Devices Testing Center,Peking University School and Hospital of Stomatology,Beijing,PR China [2]Central Laboratory,Peking University School and Hospital of Stomatology,Beijing,PR China [3]School of Medical and Life Sciences,Sunway University,Subang Jaya,Malaysia [4]Department of Geriatric Dentistry,Peking University School and Hospital of Stomatology,Beijing,PR China [5]National Engineering Research Center of Oral Biomaterials and Digital Medical Devices,NMPA Key Laboratory for Dental Materials,Beijing Laboratory of Biomedical Materials&Beijing Key Laboratory of Digital Stomatology,Peking University School and Hospital of Stomatology,Beijing,People's Republic of China

出　　处：《Animal Models and Experimental Medicine》2023年第2期120-130,共11页动物模型与实验医学（英文）

基　　金：the National Key Research and Development Program of China,Grant/Award Number:2021YFB3800800 and 2021YFC2400400;National Natural Science Foundation of China,Grant/Award Number:82022016,51973004,81991505 and 52103312;the Beijing Municipal Natural Science Foundation,Grant/Award Number:7222226;National Program for Multidisciplinary Cooperative Treatment on Major Diseases,Grant/Award Number:PKUSSNMP-202002;Peking University School of Stomatology National Clinical Key Discipline Construction Project,Grant/Award Number:PKUSSNKP-T202101。

摘　　要：Understanding the bioelectrical properties of bone tissue is key to developing new treatment strategies for bone diseases and injuries,as well as improving the design and fabrication of scaffold implants for bone tissue engineering.The bioelectrical properties of bone tissue can be attributed to the interaction of its various cell lineages(osteocyte,osteoblast and osteoclast)with the surrounding extracellular matrix,in the presence of various biomechanical stimuli arising from routine physical activities;and is best described as a combination and overlap of dielectric,piezoelectric,pyroelectric and ferroelectric properties,together with streaming potential and electro-osmosis.There is close interdependence and interaction of the various electroactive and electrosensitive components of bone tissue,including cell membrane potential,voltage-gated ion channels,intracellular signaling pathways,and cell surface receptors,together with various matrix components such as collagen,hydroxyapatite,proteoglycans and glycosaminoglycans.It is the remarkably complex web of interactive cross-talk between the organic and non-organic components of bone that define its electrophysiological properties,which in turn exerts a profound influence on its metabolism,homeostasis and regeneration in health and disease.This has spurred increasing interest in application of electroactive scaffolds in bone tissue engineering,to recapitulate the natural electrophysiological microenvironment of healthy bone tissue to facilitate bone defect repair.

关 键 词：BONE dielectric electric FERROELECTRIC HOMEOSTASIS METABOLISM piezoelectric PYROELECTRIC REGENERATION 

分 类 号：R336[医药卫生—人体生理学]