Bioproduction of monoterpene indole alkaloids in a single cell factory  

作　　者：Jianping Huang Shengxiong Huang 

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China,and CAS Center for Excellence in Molecular Plant Sciences,Kunming Institute of Botany,Chinese Academy of Sciences,Kunming 650201,China [2]State Key Laboratory of Southwestern Chinese Medicine Resources,Innovative Institute of Chinese Medicine and Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China

出　　处：《Engineering Microbiology》2022年第4期68-70,共3页工程微生物学（英文）

基　　金：supported by the National Key R&D Program of China(2018YFA0900600);the Strategic Priority Research Program of the CAS(XDB27020205).

摘　　要：The de novo biosynthesis of vindoline and catharanthine,the direct precursors used for industrial production of the anti-cancer drug vinblastine,has been achieved in the yeast cell factory.To date,this is the longest natural product biosynthesis pathway that has been successfully transferred from plants to microorganisms,indicating the possibility of producing more than 3,000 other monoterpene indole alkaloids in yeast by synthetic genome engineering.

关 键 词：Monoterpene indole alkaloids VINBLASTINE YEAST Synthetic biology 

分 类 号：Q813[生物学—生物工程] R97[医药卫生—药品]