VINBLASTINE

作品数：14被引量：32H指数：3
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相关领域：医药卫生生物学更多>>
相关机构：中山医学大学浙江理工大学暨南大学更多>>
相关期刊：《Science China Chemistry》《World Journal of Gastroenterology》《Plant Communications》《Asian Journal of Pharmaceutical Sciences》更多>>
相关基金：国家自然科学基金广东省自然科学基金更多>>
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A near-complete genome assembly of Catharanthus roseus and insights into its vinblastine biosynthesis and high susceptibility to the Huanglongbing pathogen
《Plant Communications》2023年第6期216-220,共5页Zhongping Xu Guanying Wang Qiongqiong Wang Xiaoting Li Guangyu Zhang Ali Qurban Can Zhang Yi Zhou Huan Si Lisong Hu Fuqiu Wang Ying Wang Zhitao Tian Wei Chen Shuangxia Jin Fang Ding 
supported by grants from the National Natural Science Foundation of China(31872077);the National Key Research and Development Program of China(2021YFD1400800);Special Projects for Foreign Cooperation of Yunnan Province(no.202003AD150014)to F.D.
Dear Editor,Catharanthus roseus,an important medicinal plant native to Madagascar,is the sole source of the two important anticancer drugs vinblastine and vincristine,which are synthesized by the monoterpene-derived i...
关键词：drugs LYMPHOCYTIC 
De novo biosynthesis of a vinblastine precursor in Pichia pastoris
《Synthetic and Systems Biotechnology》2023年第2期300-301,共2页Jiaming Yu Dongyuan Lv Lixin Zhang 
Plant natural products have been widely used in medicine,food,and cosmetics.Of a particular note,many natural products from Cathar-anthus roseus have important biological activities and medicinal value^([1]),with vinb...
关键词：products. synthesis PREPARATION 
Bioproduction of monoterpene indole alkaloids in a single cell factory
《Engineering Microbiology》2022年第4期68-70,共3页Jianping Huang Shengxiong Huang 
supported by the National Key R&D Program of China(2018YFA0900600);the Strategic Priority Research Program of the CAS(XDB27020205).
The de novo biosynthesis of vindoline and catharanthine,the direct precursors used for industrial production of the anti-cancer drug vinblastine,has been achieved in the yeast cell factory.To date,this is the longest ...
关键词：Monoterpene indole alkaloids VINBLASTINE YEAST Synthetic biology 
Reprograming yeast for anti-cancer vinblastine synthesis
《Life Metabolism》2022年第3期207-208,共2页Tian Ma Zixin Deng 
In a recent study published in Nature,Zhang et al.employed an innovative approach by reprogramming and engineering yeast strain for combined biosynthesis of vindoline and catharanthine,followed by an additional in vit...
关键词：SYNTHESIS PROGRAMMING ALKALOIDS 
The FAPα-activated prodrug Z-GP-DAVLBH inhibits the growth and pulmonary metastasis of osteosarcoma cells by suppressing the AXL pathway被引量：3
《Acta Pharmaceutica Sinica B》2022年第3期1288-1304,共17页Geni Ye Maohua Huang Yong Li Jie Ouyang Minfeng Chen Qing Wen Xiaobo Li Huhu Zeng Pei Long Zepei Fan Junqiang Yin Wencai Ye Dongmei Zhang 
supported by National Natural Science Foundation of China(grant numbers:82003796,81803566,81973340 and 81630095);Local Innovative and Research Teams Project of the Guangdong Pearl River Talents Program(grant number:2017BT01Y036,China);National High-level Personnel of the Special Support Program(DM Zhang,China);National Science and Technology Major Project(grant number:2018ZX09711001008-008,China);Key-Area Research and Development Program of Guangdong Province(grant number:2020B1111110004,China);Natural Science Foundation of Guangdong Province(grant number:2019A1515010144,China);Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research,College of Pharmacy(grant number:2020B1212060076,China);Special Funds for the Cultivation of Guangdong College Students’Scientific and Technological Innovation(grant number:pdjh2021a0052,China)。
Osteosarcoma is a kind of bone tumor with highly proliferative and invasive properties,a high incidence of pulmonary metastasis and a poor prognosis.Chemotherapy is the mainstay of treatment for osteosarcoma.Currently...
关键词：OSTEOSARCOMA Fibroblast activation protein alpha GROWTH Pulmonary metastasis Vinblastine prodrug AXL β-Catenin 
Current advances in Hodgkin’s lymphoma
《Chronic Diseases and Translational Medicine》2019年第1期15-24,共10页Joseph Vadakara Benjamin Andrick 
Hodgkin’s lymphoma is a highly treatable malignancy. It has high cure rates yet there are many patients who relapse or are refractory to treatment. Traditionally, treatment has been with conventional chemotherapy;how...
关键词：Hodgkin’s LYMPHOMA Brentuximab vedotin Nivolumab Pembrolizumab Doxorubicin  bleomycin  vinblastine  and DACARBAZINE (ABVD) 
Molecularly imprinted nanoparticles and their releasing properties, bio-distribution as drug carriers被引量：2
《Asian Journal of Pharmaceutical Sciences》2017年第2期172-178,共7页Yongyan Zhu Ling Yang Dandan Huang Quanhong Zhu 
supported by the National Natural Science Foundation of China (grant number: 81173566)
Molecular imprinted nanoparticles(MINPs) can memorize the shape and functional group positions complementary to template, which account for the large drug loading capacity and slow drug release behavior as drug carrie...
关键词：Molecular imprinted NANOPARTICLES VINBLASTINE Drug CARRIER SUSTAINED release Liver TARGETING 
Biosynthetic pathway of terpenoid indole alkaloids in Catharanthus roseus被引量：8
《Frontiers of Medicine》2014年第3期285-293,共9页Xiaoxuan Zhu Xinyi Zeng Chao Sun Shilin Chen 
Catharanthus roseus is one of the most extensively investigated medicinal plants, which can produce more than 130 alkaloids, including the powerful antitumor drugs vinblastine and vincristine. Here we review the recen...
关键词：Catharanthus roseus terpenoidindole alkaloids biosynthetic pathway VINBLASTINE VINCRISTINE 
Long Lasting Efficiency of Monthly Vinblastine in a Case of Relapsed Anaplastic Large Cell Lymphoma
《Open Journal of Blood Diseases》2013年第2期63-64,共2页Ratha Mlis Matthias Schell Perrine Marec Bérard Nathalie Bleyzac Didier Frappaz 
Nearly 40% of children with Anaplastic Large cell lymphomas will relapse after a first-line strategy with short-pulse chemotherapy and reach a second remission in 30% to 60% with second line therapies including mainte...
关键词：ANAPLASTIC Large Cell LYMPHOMA VINBLASTINE 
Non-AIDS-related Kaposi’s sarcoma:A single-institution experience
《World Journal of Clinical Oncology》2013年第2期52-57,共6页Pasquale Rescigno Rossella Di Trolio Carlo Buonerba Gaia De Fata Piera Federico Davide Bosso Antonella Virtuoso Michela Izzo Tania Policastro Luca Vaccaro Gianfranco Cimmino Francesco Perri Elide Matano Mario Delfino Sabino De Placido Giovannella Palmieri Giuseppe Di Lorenzo 
AIM:To evaluate the outcomes and potential prognostic factors in patients with non-acquired immunodeficiency syndrome(AIDS)-related Kaposi’s sarcoma(KS).METHODS:Patients with histologically proven non-AIDS-related KS...
关键词：Kaposi’s SARCOMA Human HERPES virus 8 PACLITAXEL Pegylated LIPOSOMAL DOXORUBICIN VINBLASTINE 
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