LIPOSOMAL

作品数：92被引量：300H指数：9
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相关领域：医药卫生更多>>
相关作者：张强张华王静张大卫王桂玲更多>>
相关机构：北京大学河北医科大学吉林大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金王宽诚敎育基金更多>>
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Intratumoral lactic acid neutralization strategy for boosting chemoimmunotherapy using liposomal sodium bicarbonate
《Science Bulletin》2024年第24期3936-3948,共13页Taoxing Peng Xinyue Shao Wenqin Song Weihua Xu Wei Xiong Yihao He Yang Ding Yongzhuo Huang 
the National Key Research and Development Program of China(2021YFC400600,2022YFE0203600);the National Natural Science Foundation of China(81925035 and 82341232);the Future Network(083GJHZ2023012FN);Grand Challenges(083GJHZ2023021GC)of the International Partnership Program of the Chinese Academyof Sciences,CAS President’s International Fellowship Initiative(2024VBB0004);High-level Innovative Research Institute(2021B0909050003)from Department of Science;Technology of Guangdong Province;Zhongshan Municipal Bureau of Science and Technology(LJ2021001 and CXTD2022011).
Glycolysis-related lactic acid overproduction creates an“ion-trapping”barrier and immunosuppressive tumor microenvironment that compromise effective intratumoral drug delivery and therapy.Therefore,normalization of ...
关键词：Sodium bicarbonate Lactic acid neutralization Tumor microenvironment normalization CHEMOIMMUNOTHERAPY PD-1 antibody Ion-trapping barrier 
Development of a multi-level pH-responsive lipid nanoplatform for efficient co-delivery of si RNA and small-molecule drugs in tumor treatment
《Chinese Chemical Letters》2024年第12期265-272,共8页Yunjie Dang Yanru Feng Xiao Chen Chaoxing He Shujie Wei Dingyang Liu Jinlong Qi Huaxing Zhang Shaokun Yang Zhiyun Niu Bai Xiang 
supported by the grants from the National Natural Science Foundation of China(Nos.81973251 and 81302725);Hebei Province Funding Project for Introduced Overseas Personnel(Nos.C20230351 and C20220345);Key Research and Development Program of Hebei Province(No.22372701D);Hebei Province Natural Science Fund(No.H2020206610);Hebei Provincial Health Commission Government-Funded Clinical Medicine Talent Program(No.ZF2024048);Hebei Medical University Undergraduate Innovative Experiment Program(No.USIP2023008)。
The combination of nucleic acid and small-molecule drugs in tumor treatment holds significant promise;however,the precise delivery and controlled release of drugs within the cytoplasm encounter substantial obstacles,i...
关键词：Cyclic peptides siRNA Liposomal platform Multi-level pH-responsive CO-DELIVERY 
Neutrophil-targeted liposomal platform: A shift in novel approach for early detection and treatment of cancer metastasis
《Asian Journal of Pharmaceutical Sciences》2024年第5期182-201,共20页Cong Li Kexin Zhang Zehua Cheng Lihong Wang Zehao Li Chao Shen Zhihang Li Zeyu Wang Lianrui Cao Lijiang Chen 
This work was supported by the Doctoral Start-up Foundation of Liaoning Province of China[Grant Number 2023-BS-086];the Fundemental Research Funds for Public Universitiesin Liaoning(LJKJT202402);the Youth Project of Liaoning Provincial Department of Education(JYTQN2023188);the Youth Scientific Research Fund Project of Liaoning University.
Tumormetastasis is responsible for 90%of cancer-associated deaths,and its early detection may decrease the likelihood of mortality.Studies have demonstrated that metastasis results from the interaction between“seeds...
关键词：Lung metastasis Early depletion LIPOSOME NEUTROPHIL Sialic acid Pre-metastatic niche 
Rational design of a nonclassical liposomal nanoscale drug delivery system for innovative cancer therapy被引量：1
《BMEMat(BioMedical Engineering Materials)》2024年第3期51-73,共23页Chunjie Wang Xiaoqi Sun Liangzhu Feng Zhuang Liu 
National Research Programs from the Ministry of Science and Technology of China,Grant/Award Numbers:2021YFF0701800,2022YFF0706500;National Natural Science Foundation of China,Grant/Award Numbers:22077093,32322046;Collaborative Innovation Center of Suzhou Nano Science and Technology;111 Program from the Ministry of Education of China;Suzhou Key Laboratory of Nanotechnology and Biomedicine;Natural Science Foundation of Jiangsu Province,Grant/Award Number:BK20220110。
Advanced drug delivery systems are widely considered to be powerful approaches for treating cancer and many other diseases because of their superior ability to improve pharmacokinetics,promote lesion-targeted delivery...
关键词：cancer therapy drug delivery lipid bilayer nonclassical liposomal nanoparticles 
Liposomalα-cyperone targeting bone resorption surfaces suppresses osteoclast differentiation and osteoporosis progression via the PI3K/Akt axis
《Nano Research》2024年第4期2949-2959,共11页Lin Yang Xueying An Wang Gong Wenshu Wu Bin Liu Xiaoyan Shao Yansi Xian Rui Peng Baosheng Guo Qing Jiang 
supported by the National Key Research and Development Project(No.2021YFA1201404);Major Project of the National Natural Science Foundation of China(Nos.81991514,82272530);Jiangsu Province Medical Innovation Center of Orthopedic Surgery(No.CXZX202214);Jiangsu Provincial Key Medical Center Foundation,Jiangsu Provincial Medical Outstanding Talent Foundation,Jiangsu Provincial Medical Youth Talent Foundation,Jiangsu Provincial Key Medical Talent Foundation;the Fundamental Research Funds for the Central Universities(Nos.14380493 and 14380494).
Osteoporosis is a metabolic dysregulation of bone that occurs mainly in postmenopausal women,and the hyperfunction of osteoclasts is the primary contributor to postmenopausal osteoporosis.However,the development of ef...
关键词：OSTEOPOROSIS Α-CYPERONE OSTEOCLAST phosphoinositide 3-kinase/protein kinase B(PI3K/Akt) liposome 
Photo-manipulated polyunsaturated fatty acid-doped liposomal hydrogel for flexible photoimmunotherapy
《Chinese Chemical Letters》2024年第4期268-274,共7页Xinyue Lan Junguang Liang Churan Wen Xiaolong Quan Huimin Lin Qinqin Xu Peixian Chen Guangyu Yao Dan Zhou Meng Yu 
supported by the Natural Science Foundation of Guangdong Province (No.2023A1515030291);Science and Technology Program of Guangzhou (No.202201011130280065);National Natural Science Foundation of China (No.82172079);Special Fund of Foshan Climbing Peak Plan (No.2020B018)。
Despite the synergy of immune checkpoint blockade(ICB) therapy and photodynamic therapy(PDT) holds great promise as countermeasures against breast cancer, exploring long-term or flexible short-time therapeutic strateg...
关键词：Photodynamic therapy IMMUNOTHERAPY Responsive release Immunogenic cell death Liposomal hydrogel 
Epigenetic-based combination therapy and liposomal codelivery overcomes osimertinib-resistant NSCLC via repolarizing tumor-associated macrophages
《Acta Pharmacologica Sinica》2024年第4期867-878,共12页Ting-ting Lin Wei Xiong Gui-hua Chen Yang He Li Long Xin-fu Gao Jia-lin Zhou Wen-wen Lv Yong-zhuo Huang 
supported by the National Key Research and Development Program of China(2021YFC2400600,2021YFE0103100);NFSC(81925035);Department of Science and Technology of Guangdong Province(High-level new R&D institute 2019B090904008,High-level Innovative Research Institute 2021B0909050003);the Scientific and Technological Innovation Leading Talent Project in Zhongshan City(LJ2021001);the Scientific Research and Innovation Team Project in Zhongshan City(CXTD2022011);and Research Foundation of Binzhou Medical University(BY2019KJ03).
Osimertinib (Osi) is widely used as a first-line treatment for non-small cell lung cancer (NSCLC) with EGFR mutations. However, the majority of patients treated with Osi eventually relapse within a year. The mechanism...
关键词：osimertinib resistance targeted drug delivery liposomes PANOBINOSTAT tumor-associated macrophage combination therapy 
Liposomal dual delivery systems in visceral leishmaniasis enhance the synergistic effects of combination therapy:A promise for the future
《Asian Pacific Journal of Tropical Medicine》2024年第2期47-60,共14页Raghunath Hazra Amrita Kar Santanu Kar Mahapatra 
SKM gratefully acknowledges the support of Indian Council of Medical Research(ICMR),New Delhi,India(File No:6/9-7(308)/2023-ECD-II);RH acknowledges the SVMCM fellowship,West Bengal.
Visceral leishmaniasis(VL)is a neglected tropical disease,and this review has summarized the current treatment scenario and its prospects.It also highlights alternative approaches used by research groups in India and ...
关键词：Visceral leishmaniasis Liposomal anti-leishmanial drug Dual drug liposome 
Synergistic chemotherapy/PTT/oxygen enrichment by multifunctional liposomal polydopamine nanoparticles for rheumatoid arthritis treatment
《Asian Journal of Pharmaceutical Sciences》2024年第1期86-102,共17页Xiaoling Fu Yutong Song Xianquan Feng Zhihong Liu Wenhao Gao Hongtao Song Qian Zhang 
Amultifunctional liposomal polydopamine nanoparticle(MPM@Lipo)was designed in this study,to combine chemotherapy,photothermal therapy(PTT)and oxygen enrichment to clear hyperproliferating inflammatory cells and improv...
关键词：POLYDOPAMINE Thermosensitive liposomes Photothermal therapy Oxygen generation Rheumatoid arthritis 
Immune checkpoint inhibition mediated with liposomal nanomedicine for cancer therapy
《Military Medical Research》2024年第1期98-114,共17页Guang-Long Ma Wei-Feng Lin 
supported by the National Science Fund for Distinguished Young Scholars(Overseas).
Immune checkpoint blockade(ICB)therapy for cancer has achieved great success both in clinical results and on the market.At the same time,success drives more attention from scientists to improve it.However,only a small...
关键词：LIPOSOME EXOSOME Immune checkpoint blockade(ICB) 
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