An 83-year-old woman had been diagnosed with a left frontal apex mass for more than 20 years without any symptoms. Recently, the rate of protrusion of the perceived mass increased rapidly. Malignant lesions were consi...
Background: A number of meningeal neoplastic lesions may radiologically and clinically simulate meningioma, include hemangiopericytomas, solitary fibrous tumors, schwannomas, hematolymphoid lesions, metastases, and ot...
the National Key R&D Program of China(2021YFE0206400);the National Natural Science Foundation of China(81603031);the Natural Science Foundation of Zhejiang Province(LQ21H300007);the Young Elite Scientists Sponsorship Program by CPU(131810011 and 1132010013).
Anaplastic lymphoma kinase(ALK),a tyrosine receptor kinase,has been proven to be associated with the occurrence of numerous malignancies.Although there have been already at least 3 generations of ALK inhibitors approv...
Supported by the 2023 Yeungnam University Research Grant.
BACKGROUND Anaplastic thyroid cancer(ATC)is a rare but aggressive type of thyroid carcinoma.BRAF V600E-mutation,which is found in 10%-50%of ATCs,is associated with poor prognosis.A recent clinical trial reported a sub...
BACKGROUND Myxopapillary ependymoma(MPE)is a pathological grade I tumor that arises in the filum terminale.MPE with anaplastic features is extremely rare,and only 5 cases have shown malignancy at the time of recurrenc...
Supported by National Science and Technology Major Subproject of China,No.2018ZX10302205-002;Chinese Foundation for Hepatitis Prevention and Control-Tianqing Liver Disease Research Fund Subject,No.TQGB2020168.
BACKGROUND Primary bone lymphoma(PBL)is an uncommon extranodal disease that represents approximately 1%-3%of lymphomas.Anaplastic lymphoma kinase(ALK)positive anaplastic large-cell lymphoma(ALCL)is an extremely rare t...
Most meningiomas are benign;however anaplastic meningiomas are usually highly invasive and grow rapidly. These tumors can metastases outside the blood-brain barrier occurring to the lungs. We present an unusual case o...
The study was supported by grants from the National Natural Science Foundation of China(No.81400166);the Key Research and Development Program of Shandong Province(No.2018GSF118157).
As a morphological sub-type of multiple myeloma(MM),anaplastic myeloma(AM),which includes anaplastic multiple myeloma and anaplastic plasmacytoma,is a rare disease that aggressively progresses.It is reported to be ver...
Supported by the Special Fund of the Pediatric Medical Coordinated Development Center of Beijing Hospitals Authority,No.XTZD20180204。
BACKGROUND The aberrant expression of the anaplastic lymphoma kinase(ALK)gene in ALKpositive(ALK+)anaplastic large cell lymphoma(ALCL)is usually due to t(2;5)/NPM-ALK.However,rarely,aberrant ALK expression can also re...
BACKGROUND Anaplastic sarcoma of the kidney(ASK)is a rare and newly recognized renal neoplasm.The tumor usually is extensive and cystic,characterized by pleomorphic spindle cells with marked atypia and associated with...