Metformin suppresses calcium oxalate crystal-induced kidney injury by promoting Sirt1 and M2 macrophage-mediated anti-inflammatory activation  

作　　者：Haoran Liu Chen Duan Xiaoqi Yang Jianhe Liu Yaoliang Deng Hans-Göran Tiselius Zhangqun Ye Tao Wang Jinchun Xing Hua Xu 

机构地区：[1]Department of Urology,The First Affiliated Hospital of Anhui Medical University,230000,Hefei,China [2]Bio-X,Stanford University,94303,Stanford,California,USA [3]Department of Urology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,430000,Wuhan,China [4]Department of Urology,The Second Affiliated Hospital of Kunming Medical University,650000,Kunming,China [5]Department of Urology,The First Affiliated Hospital of Guangxi Medical University,530000,Nanning,China [6]Division of Urology,Department of Clinical Sciences,Intervention and Technology,Karolinska Institutet,13820,Stockholm,Sweden [7]Department of Urology,The First Affiliated Hospital of Xiamen University,361000,Xiamen,China [8]Cancer Precision Diagnosis and Treatment and Translational Medicine Hubei Engineering Research Center,430000,Wuhan,China [9]Department of Biological Repositories,Zhongnan Hospital of Wuhan University,430000,Wuhan,China [10]Department of Urology,Zhongnan Hospital of Wuhan University,430000,Wuhan,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第2期373-376,共4页信号转导与靶向治疗（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(82070726,82060137,81970604,and 82100808);the Key Project of the Guangxi Natural Science Foundation(2020GXNSFDA297013);the China Postdoctoral Science Foundation(2021M690185);the Anhui Postdoctoral Science Foundation(2021A482);the Anhui Provincial Department of Education Research Project(KJ2020A0167).

摘　　要：Dear Editor,Kidney stones are one of the most common clinical diseases in urology.Approximately 80%of renal calculi are composed of calcium oxalate(CaOx)crystals,which are gradually deposited in the medullary collecting duct or in the renal interstitium,causing nephrocalcinosis.1 Although CaOx nephrocalcinosis is usually asymptomatic.

关 键 词：KIDNEY clinical DISEASES 

分 类 号：R692[医药卫生—泌尿科学]