Neuroimmune,clinical and treatment challenges in multiple sclerosis-related psychoses  

作　　者：Katarina Vesic Aleksandar Gavrilovic Nataša R Mijailović Milica M Borovcanin 

机构地区：[1]Department of Neurology,University of Kragujevac,Faculty of Medical Sciences,Kragujevac 34000,Sumadija,Serbia [2]Department of Pharmacy,University of Kragujevac,Faculty of Medical Sciences,Kragujevac 34000,Sumadija,Serbia [3]Department of Psychiatry,University of Kragujevac,Faculty of Medical Sciences,Kragujevac 34000,Sumadija,Serbia

出　　处：《World Journal of Psychiatry》2023年第4期161-170,共10页世界精神病学杂志

基　　金：Supported by Ministry of Science and Technological Development of the Republic of Serbia,No.175069.

摘　　要：In recent years,epidemiological and genetic studies have shown an association between autoimmune diseases and psychosis.The question arises whether patients with schizophrenia are more likely to develop multiple sclerosis(MS)later in life.It is well known that the immune system plays an important role in the etiopathogenesis of both disorders.Immune disturbances may be similar or very different in terms of different types of immune responses,disturbed myelination,and/or immunogenetic predispositions.A psychotic symptom may be a consequence of the MS diagnosis itself or a separate entity.In this review article,we discussed the timing of onset of psychotic symptoms and MS and whether the use of corticosteroids as therapy for acute relapses in MS is unfairly neglected in patients with psychiatric comorbidities.In addition,we discussed that the anti-inflammatory potential of antipsychotics could be useful and should be considered,especially in the treatment of psychosis that coexists with MS.Autoimmune disorders could precipitate psychotic symptoms,and in this context,autoimmune psychosis must be considered as a persistent symptomatology that requires continuous and specific treatment.

关 键 词：Multiple sclerosis PSYCHOSIS Schizophrenia CORTICOSTEROIDS ANTIPSYCHOTICS 

分 类 号：R744.51[医药卫生—神经病学与精神病学]