Single-cell transcriptome profiling of human HSCs during development:new insights into HSC ontogeny  

作　　者：Edgar Grinstein Csaba Mahotka 

机构地区：[1]Department of Hematology,Oncology and Clinical Immunology,Medical Faculty,Heinrich Heine University,Düsseldorf,Germany [2]Institute of Pathology,Medical Faculty,Heinrich Heine University,Düsseldorf,Germany

出　　处：《Signal Transduction and Targeted Therapy》2023年第3期877-878,共2页信号转导与靶向治疗（英文）

基　　金：The work was supported by grants from the Forschungskommission of the Medical Faculty of the Heinrich Heine University of Düsseldorf and the Leukämie Lymphom Liga e.V.to E.Grinstein.Acknowledged is furthermore grant support from Deutsche Forschungsgemeinschaft to E.Grinstein.

摘　　要：A study recently published in Nature reported a single-cell transcriptome map of human hematopoietic stem cells(HSCs)and a gene expression signature that distinguishes nascent HSCs from non-HSCs during prenatal development.1 This transcriptome map provides an important tool for further elucidation of human HSC ontogeny and could also serve as a guide for generation of transplantable HSCs ex vivo,1 to widen the therapeutic application of HSCs.

关 键 词：HSCS TRANSCRIPTOME HEMATOPOIETIC 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]