HSCS

作品数：90被引量：367H指数：11
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NUMB endocytic adaptor protein(NUMB)mediates the anti-hepatic fibrosis effect of artesunate(ART)by inducing senescence in hepatic stellate cells(HSCs)
《Chinese Journal of Natural Medicines》2025年第3期322-333,共12页Yangling Qiu Yujia Li Mengran Li Yingqian Wang Min Shen Jiangjuan Shao Feng Zhang Xuefen Xu Feixia Wang Zili Zhang Shizhong Zheng 
supported by the National Natural Science Foundation of China(Nos.82474164,82374124,82073914,82173874,82274185,82305046 and 82304902);the Natural Science Foundation of Jiangsu Province(Nos.BK20230458 and BK20220467);the General Project of the Natural Science Research of Jiangsu Higher Education Institutions(No.23KJB310017);Young Elite Scientists Sponsorship Program by CACM(No.2022-QNRC2-B15).
Developing and identifying effective medications and targets for treating hepatic fibrosis is an urgent priority.Our previous research demonstrated the efficacy of artesunate(ART)in alleviating liver fibrosis by elimi...
关键词：Hepatic stellate cells NUMB endocytic adaptor protein SENESCENCE ARTESUNATE UBIQUITYLATION Liver fibrosis 
Halt aging? — functional HSCs lead the way
《Cell Research》2025年第3期157-158,共2页Rebecca T.Chu Adam B.Schroer Saul A.Villeda 
The aged immune system contributes to systemic aging,serving as a driver of morbidity and mortality in the elderly.In a recent Cell Research paper,Wang et al.identified both resilient and dysfunctional subsets of old ...
关键词：hematopoietic stem cells hscs dysfunctional hscs immune system cell research aging phenotypes functional hscs therapeutic targets systemic aging hematopoietic stem cells 
Reducing functionally defective old HSCs alleviates agingrelated phenotypes in old recipient mice
《Cell Research》2025年第1期45-58,共14页Yuting Wang Wenhao Zhang Chao Zhang Hoang QTran Van Takashi Sein Yi Zhang 
Aging is a process accompanied by functional decline in tissues and organs with great social and medical consequences.Developing effective anti-aging strategies is of great significance.In this study,we demonstrated t...
关键词：HSCS ORGANS aging 
Chimeric antigen receptor T cells targeting CD312 as a therapy for acute myeloid leukemia
《Chinese Medical Journal》2025年第1期114-116,共3页Danni Xie Bing Wang Xue Bai Xin Jin Wenyi Lu Meng Zhang Yi Zhang Xinping Cao Mingfeng Zhao 
supported by grants from the General Project of the National Natural Science Foundation of China(No.81970180);the Science and Technology Project of Tianjin Municipal Health Committee(No.TJWJ2022QN030);the Key Projects of Tianjin Applied Basic Research and Multi-Investment Fund(No.21JCZDJC01240);the Science and Technology Project of Tianjin Municipal Health Committee(No.TJWJ2022XK018);the Tianjin Key Medical Discipline(Specialty)Construction Project(No.TJYXZDXK-056B);the Tianjin Municipal Natural Science Foundation(No.22JCQNJC00820);the Tianjin Health Research Project(No.TJWJ2023QN027);the Tianjin Health Bureau Project(No.ZC20074);the Tianjin Key Medical Discipline(Specialty)Construction Project(No.TJWJ2023XK010).
To the Editor:Chimeric antigen receptor(CAR)-T-cell therapy has made considerable breakthroughs in the treatment of lymphoma and myeloma,but the lack of suitable or specific targets for acute myelocytic leukemia(AML)h...
关键词：CAR T Cell Therapy Hematopoietic Stem Cells Target Antigen hematopoietic stem cells hscs making Acute Myeloid Leukemia Chimeric Antigen Receptor T Cells 
YTHDF1调控Fis1对肝星状细胞活化、增殖及迁移能力的影响
《安徽医科大学学报》2025年第1期49-58,共10页贾琳 孙峰 董琪琪 杨晶晶 周仁鹏 胡伟 鲁超 
国家自然科学基金资助项目(编号:81600477);安徽高校自然科学基金资助项目(编号:KJ2020A0181);安徽医科大学第二附属医院国家自然科学基金孵育计划(编号:2019GMFY07);安徽省重点研究与开发计划项目(编号:202204295107020035);安徽省自然科学基金面上项目(编号:2208085MH215);合肥综合性国家科学中心大健康研究院职业医学与健康联合研究中心项目(编号:OMH-2023-03)。
目的探究YTH结构域家族蛋白1(YTHDF1)调控线粒体分裂蛋白1(Fis1)介导的线粒体裂变对肝星状细胞(HSCs)活化、增殖和迁移能力的影响。方法应用5 ng/ml TGF-β1处理小鼠肝星状细胞株JS-124 h以诱导其活化和增殖,并使用YTHDF1-siRNA构建YTH...
关键词：YTHDF1 Fis1 HSCS 活化 增殖 迁移 肝纤维化 
Hemodialysis bilayer bionic blood vessels developed by the mechanical stimulation of hepatitis B viral X(HBX)genetransfected hepatic stellate cells
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第6期499-512,共14页Hongyi LIU Yuanyuan ZHOU Peng GUO Xiongwei ZHENG Weibin CHEN Shichao ZHANG Yu FU Xu ZHOU Zheng WAN Bin ZHAO Yilin ZHAO 
supported by the National Natural Science Foundation of China(No.81770294);the Natural Science Foundation of Fujian Province(No.2023J05261),China.
Artificial vascular graft(AVG)fistula is widely used for hemodialysis treatment in patients with renal failure.However,it has poor elasticity and compliance,leading to stenosis and thrombosis.The ideal artificial bloo...
关键词：Composite bilayer bionic blood vessel Extracellular matrix(ECM) Hepatic stellate cells(HSCs) Hepatitis B viral X(HBX)gene Mechanical force 
编委推荐
《遗传》2024年第3期181-182,共2页
Cell Stem Cell|从人类诱导多能干细胞生成无转基因的造血干细胞造血干细胞(hematopoietic stem cells,HSCs)是终身治疗性造血细胞移植的关键细胞。近几十年来,对临床级别的HSCs需求显著增加,治疗患者面临重大困难。一个有希望但尚未实...
关键词：造血干细胞 诱导多能干细胞 细胞工程 终身治疗 Laurence HSCS Cell 
Remodeling of the liver fibrosis microenvironment based on nilotinib-loaded multicatalytic nanozymes with boosted antifibrogenic activity
《Acta Pharmaceutica Sinica B》2023年第12期5030-5047,共18页Huaqing Jing Yingzi Ren Yue Zhou Min Xu Sona Krizkova Zbynek Heger Qiang Lu Siyu Wang Xiaoyang Liang Vojtech Adam Nan Li 
supported by the Young Elite Scientists Sponsorship Program by Tianjin(No.0701320001,China);Major Special Projects(No.0402080005,China);National Key R&D Program of China(No.2020YFC1512304,China);National Natural Science of China(Nos.82273873,31971106,and 81372124,China);the Czech Health Council(AZV NU12J-08-00043,Czech).
Liver fibrosis is a reversible pathological process caused by chronic liver damage and a major risk factor for hepatocellular carcinoma(HCC).Hepatic stellate cell(HSC)activation is considered the main target for liver...
关键词：Liver fibrosis Microenvironment remodeling HSCS ECM Collagen HYPOXIA NILOTINIB Nanozyme 
S-nitrosylation of EMMPRIN influences the migration of HSCs and MMP activity in liver fibrosis
《Acta Biochimica et Biophysica Sinica》2023年第10期1640-1649,共10页Xinyan Zhu Zihui Tang Wei Li Xiaojuan Li Yasuko Iwakiri Fei Liu 
supported by the grants from the Natural Science Foundation of China(No.81970538);the Medical discipline Construction Project of Pudong Health Committee of Shanghai(No.PWYgf 2021-02);the Key Disciplines Group Construction Project of Shanghai Pudong New Area Health Commission(No.PWZxq2022-06);the Science and Technology Development Fund of Pudong New Area(No.PKJ2022-Y19).
The mechanism of extracellular matrix metalloproteinase inducer(EMMPRIN)in the regulation of liver fibrosis has not been clarified.This study aims to investigate the role of EMMPRIN S-nitrosylation(SNO)in the regulati...
关键词：liver fibrosis extracellular matrix metalloproteinase inducer(EMMPRIN) S-nitrosylation(SNO) matrix metalloproteinases(MMPs) cell migration 
MANF brakes TLR4 signaling by competitively binding S100A8 with S100A9 to regulate macrophage phenotypes in hepatic fibrosis被引量：2
《Acta Pharmaceutica Sinica B》2023年第10期4234-4252,共19页Chao Hou Dong Wang Mingxia Zhao Petek Ballar Xinru Zhang Qiong Mei Wei Wang Xiang Li Qiang Sheng Jun Liu Chuansheng Wei Yujun Shen Yi Yang Peng Wang Juntang Shao Sa Xu Fuyan Wang Yang Sun Yuxian Shen 
supported by the National Natural Science Foundation of China(81973336);the Joint Fund of the National Natural Science Foundation of China(U21A20345)。
The mesencephalic astrocyte-derived neurotrophic factor(MANF)has been recently identified as a neurotrophic factor,but its role in hepatic fibrosis is unknown.Here,we found that MANF was upregulated in the fibrotic li...
关键词：Hepatic fibrosis Mesencephalic astrocyte-derived neurotrophic factor Macrophage differentiation Ly6C^(high)macrophages S100A8/S100A9 TLR4 NF-κB pathway HSCs activation 
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