云南高校图书馆联盟文献共享服务平台- NILOTINIB

NILOTINIB: 作品数：20被引量：45H指数：3; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：沈佳坤周励金洁何丛沈志祥更多>>; 相关机构：上海交通大学医学院附属瑞金医院浙江大学东南大学北京大学更多>>; 相关期刊：《中国处方药》《World Journal of Meta-Analysis》《Frontiers of Medicine》《Journal of Clinical and Nursing Research》更多>>; 相关基金：国家自然科学基金更多>>

Remodeling of the liver fibrosis microenvironment based on nilotinib-loaded multicatalytic nanozymes with boosted antifibrogenic activity: 《Acta Pharmaceutica Sinica B》2023年第12期5030-5047,共18页Huaqing Jing Yingzi Ren Yue Zhou Min Xu Sona Krizkova Zbynek Heger Qiang Lu Siyu Wang Xiaoyang Liang Vojtech Adam Nan Li; supported by the Young Elite Scientists Sponsorship Program by Tianjin(No.0701320001,China);Major Special Projects(No.0402080005,China);National Key R&D Program of China(No.2020YFC1512304,China);National Natural Science of China(Nos.82273873,31971106,and 81372124,China);the Czech Health Council(AZV NU12J-08-00043,Czech).; Liver fibrosis is a reversible pathological process caused by chronic liver damage and a major risk factor for hepatocellular carcinoma(HCC).Hepatic stellate cell(HSC)activation is considered the main target for liver...; 关键词：Liver fibrosis Microenvironment remodeling HSCS ECM Collagen HYPOXIA NILOTINIB Nanozyme

Nilotinib:from animal-based studies to clinical investigation in Alzheimer's disease patients被引量：1: 《Neural Regeneration Research》2023年第4期803-804,共2页Annalisa Nobili Marcello D’Amelio Maria Teresa Viscomi; supported by Linea D.1.2021 UniversitàCattolica del S.Cuore(to MTV);by the Italian Ministry of Health(IT)[Research Grant:RF-2018-12365527,to MDA and MTV];supported by the American Alzheimer’s Association[AARG-21-851219];by Fondazione Roma(Rome,Italy)。; Since their first description in the brains of patients suffering from Alzheimer ’s disease(AD), more than 100 years ago, extracellular amyloid-β(Aβ) plaques and intracellular neurofibrillary tangles have been the ...; 关键词：ALZHEIMER AΒ DRUGS

Sudden extramedullary and extranodal Philadelphia-positive anaplastic large-cell lymphoma transformation during imatinib treatment for CML:A case report: 《World Journal of Clinical Cases》2022年第28期10339-10345,共7页Qiong Wu Yong Kang Jing Xu Wen-Can Ye Zhen-Jiang Li Wen-Feng He Yuan Song Qing-Ming Wang Ai-Ping Tang Ting Zhou; Supported by the Jiangxi“5511”Science and Technology Innovation Talent Project,No.20171BCB18003。; BACKGROUND Chronic myeloid leukemia(CML)is a malignant hematologic malignancy that can progress to blast phase with a myeloid or lymphoid phenotype.Some patients with CML can also progress to blast crisis phase;howeve...; 关键词：Chronic myeloid leukemia BCR-ABL fusion gene Imatinib mesylate Anaplastic large-cell lymphoma Philadelphia-positive NILOTINIB Case report

Clinical Effect of Imatinib,Nilotinib,and Dasatinib on Chronic Myeloid Leukemia in Chronic Phase: 《Journal of Clinical and Nursing Research》2022年第4期17-21,共5页Yudi Miao; The study was conducted to explore the effect of imatinib,nilotinib,and dasatinib in the treatment of chronic myeloid leukemia(CML)patients.Around 66 patients with CML in chronic phase were selected,subsequently the p...; 关键词：IMATINIB NILOTINIB DASATINIB Chronic myeloid leukemia Chronic phase Clinical effect

Is dose modification or discontinuation of nilotinib necessary in nilotinib-induced hyperbilirubinemia?: 《World Journal of Meta-Analysis》2021年第6期488-495,共8页You-Wen Tan; Nilotinib is a specific breakpoint cluster region-Abelson leukemia virus-tyrosine kinase inhibitor that is used as an effective first-or second-line treatment in imatinib-resistant chronic myelogenous leukemia(CML)pat...; 关键词：Tyrosine kinase inhibitors NILOTINIB Chronic myelogenous leukemia HYPERBILIRUBINEMIA Drug induced liver injure Liver injury

Analysis of the efficacy and influencing factors of nilotinib or dasatinib as second- or third-line treatment in patients with chronic myeloid leukemia in the chronic phase and accelerated phase: 《China Medical Abstracts(Internal Medicine)》2020年第2期111-112,共2页YUAN Ting; Objective To explore the efficacy and prognosis of nilotinib or dasatinib as second-or third-line treatment in patients with chronic myeloid leukemia(CML)in the chronic phase(CP)and accelerated phase(AP).Methods From ...; 关键词：PATIENTS MYELOID LEUKEMIA

Efficacy of Nilotinib versus Imatinib in Philadelphia Positive Patients with Chronic Myeloid Leukemia in Early Chronic Phase Who Have a Warning Molecular Response to Imatinib: 《Journal of Cancer Therapy》2018年第11期883-897,共15页Amen Hamdy Zaky Aly Ahmed EL Sayed Mohammed Khalifa Esraa Abdallah Abdelkariem Gadallah; Background and Objectives: Chronic myeloid leukemia (CML) accounts for approximately 15% of newly diagnosed cases of leukemia in adults. In this study, the efficacy of nilotinib at 400 mg BID is compared with imatinib...; 关键词：NILOTINIB IMATINIB PHILADELPHIA POSITIVE Chronic Myeloid Leukemia PATIENTS WARNING Molecular Response

A validated UPLC–MS/MS method for simultaneous determination of imatinib, dasatinib and nilotinib in human plasma被引量：8: 《Journal of Pharmaceutical Analysis》2017年第6期374-380,共7页Jing Zeng Hualin Cai Zhiping Jiang Qing Wang Yan Zhu Ping Xu Xielan Zhao; A sensitive, rapid, simple and economical ultra-performance liquid chromatography-tandem mass spectrometric method （UPLC-MS/MS） was developed and validated for simultaneous determination of imatinib, dasatinib and n...; 关键词：UPLC-MS/MS IMATINIB DASATINIB NILOTINIB POLYMORPHISM

Mucosal healing effect of nilotinib in indomethacin-induced enterocolitis:A rat model: 《World Journal of Gastroenterology》2015年第44期12576-12585,共10页Gozde Dervis Hakim Mujde Soyturk Mehtat Unlu Pinar Ataca Meral Karaman Ozgul Sagol Elif Borekci Osman Yilmaz; Supported by Dokuz Eylul University Research Committee; AIM: To investigate the effects of nilotinib in a rat model of indomethacin-induced enterocolitis.METHODS: Twenty-one Wistar albino female rats obtained from Dokuz Eylul University Department of Laboratory Animal Scie...; 关键词：INFLAMMATORY BOWEL disease ENTEROCOLITIS Platelet-

Superiority of allogeneic hematopoietic stem cell transplantation to nilotinib and dasatinib for adult patients with chronic myelogenous leukemia in the accelerated phase被引量：1: 《Frontiers of Medicine》2015年第3期304-311,共8页Lanping Xua Huanling Zhu Jianda Hu Depei Wu Hao Jiang Qian Jiang Xiaojun Huang; Acknowledgements The Chinese CML alliance provided the data. This work was partly supported by grants from the Collaborative Innovation Center of Hematology in China, the Key Program of the National Natural Science Foundation of China （81230013）, and the Beijing Municipal Science and Technology Commission （Nos. Z121107002812033 and Z121107002612035）.; In the tyrosine kinase inhibitor （TKI） era, imatinib is the first-line therapy for patients with chronic myeloid leukemia （CML） in chronic or accelerated phase. Although second-generation TKIs （TKI2）, including ...; 关键词：chronic myeloid leukemia IMATINIB DASATINIB NILOTINIB allogeneic hematopoietic stem cell transplantation

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