supported by grants from the National Institutes of Health,USA(R01DK125047 to AG,R21Al163503 to AG).
Hirschsprung-associated enterocolitis(HAEC)is an important cause of morbidity and the leading cause of mortality in patients with Hirschsprung disease.The pathophysiology of disease includes dysmotility of the enteric...
Necrotizing enterocolitis(NEC)is a leading cause of death from gastrointestinal disease in premature and low-birth-weight infants.Early detection of severely ischemic or necrotic bowel before perforation is rather dif...
Joint Funds for the Innovation of Science and Technology,Fujian Province,No.2020Y9139;Startup Fund for Scientific Research,Fujian Medical University,No.2019QH1141.
BACKGROUND The prevention and treatment of Hirschsprung-associated enterocolitis(HAEC)is a serious challenge in pediatric surgery.Exploring the mechanism of HAEC is conducive to the prevention of this disease.AIM To e...
BACKGROUND Currently,pediatric surgeons are challenged by a lack of consensus on the optimal management strategy(conservative or surgical)for children with Bell’s stage II necrotizing enterocolitis(NEC).AIM To evalua...
Hirschsprung’s disease(HSCR)is a congenital disorder characterized by failure of the neural crest cells to migrate and populate the distal bowel during gestation affecting different lengths of intestine leading to a ...
Viral gastroenteritis is the most common viral illness that affects the gastro-intestinal(GI)tract,causing inflammation and irritation of the lining of the stomach and intestines.Common signs and symptoms associated w...
Pseudomembranous colitis is severe inflammation of the inner lining of the colon due to anoxia,ischemia,endothelial damage,and toxin production.The majority of cases of pseudomembranous colitis are due to Clostridium ...
BACKGROUND Neuraminidase inhibitor-associated acute hemorrhagic colitis is rare.We report a case of ischemic enterocolitis that was likely caused by laninamivir.CASE SUMMARY A 54-year-old female patient with influenza...
the Digestive Medical Coordinated Development Center of Beijing Hospitals Authority,No.XXZ0505.
BACKGROUND Glycogen storage disease type Ib(GSD-Ib)is a glycogen metabolism disorder that leads to the manifestations of inflammatory bowel disease(IBD),especially Crohn’s disease(CD)-like colitis.Although biological...
BACKGROUND Hepatic portal venous gas in infants is frequently due to late presentation of necrotizing enterocolitis which is considered a relative indicator for surgical intervention.CASE SUMMARY A preterm baby underw...