IMATINIB

作品数：166被引量：451H指数：11
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相关机构：北京大学肿瘤医院中山大学哈尔滨医科大学北京肿瘤医院更多>>
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Gastrointestinal stromal tumors with an uncommon primary mutation responded well to imatinib
《Cancer Pathogenesis and Therapy》2025年第2期176-178,共3页Gilani Shahid Mujeeb Qudsia Ikram Naima Khir Ibrahim 
Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal tract,driven by mutations in the proto-oncogene c-KIT or platelet-derived growth factor alpha(PDGFRA)gene in 85%-90%...
关键词：exon mutation mesenchymal tumors tyrosine kinase inhibitor tki gastrointestinal stromal tumors IMATINIB partial response gastrointestinal stromal tumors gists 
Significance of monitoring imatinib plasma concentration in secondline treatment decisions for c-kit 11 gene-mutated gastrointestinal stromal tumors
《World Journal of Gastrointestinal Oncology》2025年第3期81-90,共10页Hai-Tao Li Yun-Yun Du Zhen Huang Jin-Jin Li Jun Zhang 
BACKGROUND For patients with advanced gastrointestinal stromal tumors(GISTs)carrying the ckit exon 11 mutation,imatinib(IM)at a standard dosage of 400 mg per day is the preferred first-line treatment.In cases where tr...
关键词：Gastrointestinal stromal tumor C-kit exon 11 IMATINIB Plasma concentration Second-line treatment 
Two different mutational types of familial gastrointestinal stromal tumors:Two case reports被引量：1
《World Journal of Gastrointestinal Oncology》2024年第9期4028-4036,共9页Xiao-Ke Wang Lu-Fan Shen Xin Yang He Su Tao Wu Peng-Xian Tao Hong-Ying Lv Tong-Han Yao Lin Yi Yuan-Hui Gu 
National Natural Science Foundation of China,No.82160842;Clinical Research Project of Research Fund of Gansu Provincial Hospital,No.23GSSYD-17;General Program of the Joint Scientific Research Fund,No.23JRRA1521.
BACKGROUND Gastrointestinal stromal tumors(GISTs)are the most common mesenchymal tumors of the gastrointestinal(GI)tract,and cases of GISTs tend to be of the disseminated type,with a global incidence of 10 to 15 cases...
关键词：Gastrointestinal stromal tumor Familial gastrointestinal stromal tumor Wild-type gastrointestinal stromal tumors PDGFRA IMATINIB Treatment Case report 
The Combination Effect of Daphne Extract and Imatinib on the Antiproliferative Activity of the K562 Cell Line
《Journal of Biosciences and Medicines》2024年第8期141-153,共13页Alireza Khorshid Jafar Nouri Nojadeh Javid Sabour Takanlu Alireza Tavasoli 
Background: Herbal medicine is well-known among the ancient medical sciences. Healing properties have been observed in some species of Daphne plant. The effect of Daphne plant extract on the K562 cell line has been pr...
关键词：DAPHNE IMATINIB APOPTOSIS Herbal Medicine BAX Bcl-2 CML 
Advances in immunotherapy of M2 macrophages and gastrointestinal stromal tumor
《World Journal of Gastrointestinal Oncology》2024年第7期2915-2924,共10页Xiao-Ke Wang Xin Yang Tong-Han Yao Peng-Xian Tao Guan-Jun Jia De-Xian Sun Lin Yi Yuan-Hui Gu 
Supported by the National Natural Science Foundation of China,No.82160842;Clinical Research Project of Research Fund of Gansu Provincial Hospital,No.23GSSYD-17.
Gastrointestinal stromal tumors(GIST)are the most common mesenchymalderived tumors of the GI tract.They can occur throughout the GI tract,and the survival time of some patients can be improved by first-line targeted t...
关键词：Gastrointestinal stromal tumor M2 macrophage Inflammatory response Programmed death receptor-1 Programmed death ligand-1 IMATINIB IMMUNOTHERAPY Targeted therapy 
A scoring system to predict molecular responses in patients with chronic myeloid leukemia in the chronic phase receiving initial imatinib therapy
《China Medical Abstracts(Internal Medicine)》2023年第2期122-123,共2页李子郁 
Objective To develop a scoring system to predict molecular responses in patients with chronic myeloid leukemia in the chronic phase(CML-CP)receiving initial imatinib therapy.Methods Data from consecutive adults with n...
关键词：PATIENTS MYELOID IMATINIB 
A SARS-CoV-2-specific CAR-T-cell model identifies felodipine,fasudil,imatinib,and caspofungin as potential treatments for lethal COVID-19
《Cellular & Molecular Immunology》2023年第4期351-364,共14页in Xia Lun-zhi Yuan Ya-hong Hu Jun-yi Liu Guo-sheng Hu Ruo-yao Qi Tian-ying Zhang Hua-long Xiong Zao-zao Zheng Hong-wei Lin Jia-mo Zhang Chao Yu Ming Zhou Jian Ma Tong Cheng Ri-rong Chen Yi Guan Ning-shao Xia Wen Liu 
Fundamental Research Funds for the Central Universities(20720200104)to LX;the Ministry of Science and Technology of China(2020YFA0112300 and 2020YFA0803600);the National Natural Science Foundation of China(82125028,U22A20320,91953114,31871319,81761128015,and 81861130370);the Natural Science Foundation of Fujian Province of China(2020J02004);the Fundamental Research Funds for the Central University(20720190145 and 20720220003)to WL;the China Postdoctoral Science Foundation(2022M720119)to ZZZ.Part of Fig.6 was drawnbyusingFigdraw.
Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)-induced cytokine storm is closely associated with coronavirus disease 2019(COVID-19)severity and lethality.However,drugs that are effective against inflammat...
关键词：COVID-19 SARS-CoV-2 CAR-T anti-inflammation NF-kB pathway 
Imatinib blocks tyrosine phosphorylation of Smad4 and restores TGF-β growth-suppressive signaling in BCR-ABL1-positive leukemia
《Signal Transduction and Targeted Therapy》2023年第4期1993-2006,共14页Lijing Wang Shuchen Gu Fenfang Chen Yi Yu Jin Cao Xinran Li Chun Gao Yanzhen Chen Shuchong Yuan Xia Liu Jun Qin Bin Zhao Pinglong Xu Tingbo Liang Hongyan Tong Xia Lin Xin-Hua Feng 
grants from NSFC(U21A20356,31730057,and 91540205)and ZNSF(LD21C070001);the Fundamental Research Funds for the Central Universities.L.W.was supported by a short-term predoctoral fellowship from the Graduate School of Zhejiang University for studying abroad.
Loss of TGF-β-mediated growth suppression is a major contributor to the development of cancers,best exemplified by loss-offunction mutations in genes encoding components of the TGF-βsignaling pathway in colorectal a...
关键词：SMAD4 PHOSPHORYLATION thereby 
Pre-Sacral Chordomas, about Two Cases and Review of the Literature
《Journal of Cancer Therapy》2023年第4期152-160,共9页Oumaima Siyouri Khaoula Alaoui Ismaili Imane Stitou Mohammed Ismaili Hajar Medyouni Jihane Chouef Lamiae Amaadour Karima Oualla Zineb Benbrahim Samia Arifi Nawfel Mellas 
The World Health Organization (WHO) defines chordoma as a malignant tumor of intermediate or low grade, developing at the expense of embryonic remnants of the notochord. These tumors represent 8.4% of all malignant bo...
关键词：Chordomas IMATINIB RADIOTHERAPY 
Primary Extra-Gastrointestinal Stromal Tumors (E-GIST) of the Liver, about Two Cases and Review of the Literature Oncology Hospital Experience at Chu Hassan II in FES
《Journal of Cancer Therapy》2023年第3期117-126,共10页Oumaima Siyouri Mohammed Ismaili Khaoula Alaoui Ismaili Imane Stitou Hajar Medyouni Jihane Chouef Lamiae Amaadour Karima Oualla Zineb Benbrahim Samia Arifi Nawfel Mellas 
Introduction: Primary extra-gastrointestinal stromal tumors (E-GIST) of the liver are rare. The clinical presentation can range from asymptomatic to bleeding or manifestations of mass effect. Cancer surgery followed b...
关键词：Extra GIST Foie IMATINIB 
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