Pre-Sacral Chordomas, about Two Cases and Review of the Literature  

作　　者：Oumaima Siyouri Khaoula Alaoui Ismaili Imane Stitou Mohammed Ismaili Hajar Medyouni Jihane Chouef Lamiae Amaadour Karima Oualla Zineb Benbrahim Samia Arifi Nawfel Mellas Oumaima Siyouri;Khaoula Alaoui Ismaili;Imane Stitou;Mohammed Ismaili;Hajar Medyouni;Jihane Chouef;Lamiae Amaadour;Karima Oualla;Zineb Benbrahim;Samia Arifi;Nawfel Mellas(Department of Oncology, University Hospital Center, Fes, Morocco)

机构地区：[1]Department of Oncology, University Hospital Center, Fes, Morocco

出　　处：《Journal of Cancer Therapy》2023年第4期152-160,共9页癌症治疗（英文）

摘　　要：The World Health Organization (WHO) defines chordoma as a malignant tumor of intermediate or low grade, developing at the expense of embryonic remnants of the notochord. These tumors represent 8.4% of all malignant bone tumors. We report 2 cases collected in the medical oncology department at the CHU Hassan II in Fes. In whom the clinical examination revealed a mass and/or signs of loco-regional compression. The tumor was located in the sacrum in both patients. The diagnosis was based on the data of the anatomopathological examination showing the association of a lobulated architecture with classic physaliphore cells and a mucoid intercellular substance. Immunohistochemistry was performed for both patients. The principle of therapeutic management was based on radiotherapy and targeted therapy since surgery was difficult given the local tumor extension.The World Health Organization (WHO) defines chordoma as a malignant tumor of intermediate or low grade, developing at the expense of embryonic remnants of the notochord. These tumors represent 8.4% of all malignant bone tumors. We report 2 cases collected in the medical oncology department at the CHU Hassan II in Fes. In whom the clinical examination revealed a mass and/or signs of loco-regional compression. The tumor was located in the sacrum in both patients. The diagnosis was based on the data of the anatomopathological examination showing the association of a lobulated architecture with classic physaliphore cells and a mucoid intercellular substance. Immunohistochemistry was performed for both patients. The principle of therapeutic management was based on radiotherapy and targeted therapy since surgery was difficult given the local tumor extension.

关 键 词：Chordomas IMATINIB RADIOTHERAPY 

分 类 号：R73[医药卫生—肿瘤]