Regeneration and functional recovery of the completely transected optic nerve in adult rats by CNTF-chitosan  

作　　者：Xiao Liu Fei Hao Peng Hao Jingxue Zhang Liqiang Wang Si-Wei You Ningli Wang Zhaoyang Yang Kwok-Fai So Xiaoguang Li 

机构地区：[1]Department of Neurobiology,School of Basic Medical Sciences,Capital Medical University,100069 Beijing,China [2]School of Engineering Medicine,Beijing Key Laboratory for Biomaterials and Neural Regeneration,Beihang University,100083 Beijing,China [3]Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Ophthalmology and Visual Sciences Key Laboratory,100005 Beijing,China [4]Department of Ophthalmology,The Third Medical Center,Chinese PLA General Hospital,100089 Beijing,China [5]Department of Ophthalmology,Xijing Hospital,The Fourth Military Medical University,710032 Xi’an,Shanxi Province,China [6]Guangdong-Hongkong-Macao Institute of CNS Regeneration,Ministry of Education CNS Regeneration Collaborative Joint Laboratory,Jinan University,510632 Guangzhou,Guangdong Province,China [7]Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory),510530 Guangzhou,Guangdong Province,China [8]Department of Ophthalmology and State Key Laboratory of Brain and Cognitive Sciences,The University of Hong Kong,999077 Hong Kong,China [9]Center for Brain Science and Brain-Inspired Intelligence,Guangdong-Hong Kong-Macao Greater Bay Area,510515 Guangzhou,Guangdong Province,China [10]Co-innovation Center of Neuroregeneration,Nantong University,226001 Nantong,Jiangsu Province,China [11]Beijing International Cooperation Bases for Science and Technology on Biomaterials and Neural Regeneration,Beijing Advanced Innovation Center for Big Data-Based Precision Medicine,Beihang University,100083 Beijing,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第3期912-915,共4页信号转导与靶向治疗（英文）

基　　金：We thank for Beijing Key Laboratory of Ophthalmology and Visual Science,School of Ophthalmology,Capital Medical University for measuring F-VEP.We thank technicians in the Core Facility Center of Capital Medical University.This work was supported by the National Natural Science Foundation of China(Grants 81941011,31730030,31971279,31900749,31771053);and Ministry of Science and Technology of China(Grants 2017YFC1104002,2017YFC1104001);Beijing Science and Technology Program(Grant Z181100001818007);National Natural Science Foundation of China(Grants 31650001,31320103903,31670988);Beijing Natural Science Foundation(Grant 7214301).

摘　　要：Dear Editor,The optic nerve,which belongs to the central nervous system(CNS),cannot regenerate when injured in adult mammals.1 Up to now,no readily translatable measures are available for repairing a severely injured optic nerve.Herein we demonstrated that ciliary neurotrophic factor(CNTF)-chitosan enabled the reconstruction and functional recovery of the adult rat visual system,thus shedding light on the clinical potential for repairing the severely injured optic nerve.

关 键 词：REGENERATION functional CNTF 

分 类 号：R-332[医药卫生]