D-Psicose intake exacerbates dextran sulfate sodium-induced colitis in mice through alteration in the gut microbiota and dysfunction of mucosal barrier  

作　　者：Xuejiao Zhang Ang Li Yuanyifei Wang Jin Wang Bowei Zhang Yan Zhang Jingmin Liu Shuo Wang 

机构地区：[1]Tianjin Key Laboratory of Food Science and Health,School of Medicine,Nankai University,Tianjin 300072,China [2]College of Food Science and Technology,Hebei Agricultural University,Baoding 071001,China

出　　处：《Food Science and Human Wellness》2024年第1期173-182,共10页食品科学与人类健康（英文）

基　　金：funded by the National Natural Science Foundation of China(No.32030083)。

摘　　要：D-Psicose,as a low-calorie rare sugar,has attracted a lot of attention in recent years for alternating to sucrose.The anti-obesity effect of D-psicose has been extensively confirmed in previous studies,however,the impact of D-psicose on colitis remains vague.Here,we firstly evaluated the effect of the D-psicose prophylactic intervention on dextran sulfate sodium-induced colitis in C57BL/6 mice.The pathological symptoms,inflammatory cytokines levels,gut microbiota composition,short chain fatty acids(SCFAs)production and colonic barrier integrity were comprehensively evaluated.The results confirmed that D-psicose intervention aggravated colitis,characterized by the exacerbation of colon shortening,increase of colonic inflammatory infiltration,and marked exaltation of disease activity indices and IL-6,IL-1βand TNF-αlevels.Further,the dysfunction of gut microbiota was identified in the psicose group.The abundance of pro-inflammatory bacteria Lachnospiraceae_NK4A136_group was significantly up-regulated while the abundance of probiotics Akkermansia and Lactobacillus were significantly down-regulated in the psicose group compared to the model group.Moreover,the production of SCFAs was suppressed in the psicose group,accompanied by a decrease in the level of mucin 2(Muc-2).Collectively,the underlying mechanism of the exacerbation of colitis by D-psicose intervention might be attributed to microbiota dysfunction accompanied by the reduction of SCFAs,which leads to the damage of the mucosal barrier and the intensifi cation of inflammatory invasion.

关 键 词：D-Psicose COLITIS Gut microbiota Short chain fatty acids Mucin 2 

分 类 号：TS201.4[轻工技术与工程—食品科学]