Diastereoselective and Enantioselective Nickel-Catalyzed Reductive Coupling of Imines and Unactivated Alkenes  

作　　者：Biao Wang Xian-Ming Liu Kai-Xiang Zhang Wei-Min Feng Li-Jun Xiao Qi-Lin Zhou 

机构地区：[1]State Key Laboratory and Institute of Elemento-Organic Chemistry,College of Chemistry,Nankai University,Tianjin 300071

出　　处：《CCS Chemistry》2023年第4期814-822,共9页中国化学会会刊（英文）

基　　金：the National Natural Science Foundation of China(Nos.21790332,91956000,22188101);the Fundamental Research Funds for the Central Universities,and the Haihe Laboratory of Sustainable Chemical Transformations for their financial support.

摘　　要：Herein we report a method for highly diastereoselective and enantioselective nickel-catalyzed reductive coupling of imines and unactivated alkenes.A monodentate chiral spiro phosphoramidite ligand is the key to controlling the enantioselectivity.This efficient,straightforward method allows for the construction of chiral benzocyclic and indole-fused cyclic amines with two contiguous stereogenic centers in good yields from readily accessible starting materials.

关 键 词：nickel catalysis ENANTIOSELECTIVE ALKENES IMINES reductive coupling 

分 类 号：O62[理学—有机化学]