大脑皮质下结构与癫痫  

Subcortical structures and epilepsy

作　　者：张琼[1] 冯莉[1] ZHANG Qiong;FENG Li(Department of Neurology,Xiangya Hospital,Central South University,National Clinical Research Center for Geriatric Disorders,Changsha 410008,Hu'nan,China)

机构地区：[1]中南大学湘雅医院神经内科、国家老年疾病临床医学研究中心,长沙410008

出　　处：《中国现代神经疾病杂志》2023年第3期156-160,共5页Chinese Journal of Contemporary Neurology and Neurosurgery

基　　金：国家重点研发计划项目(项目编号:2022YFC2503804);国家自然科学基金资助项目(项目编号:82071461);国家自然科学基金资助项目(项目编号:82271503);湖南省自然科学基金资助项目(项目编号:2021JJ31060)。

摘　　要：随着神经电生理学、神经影像学等技术的快速发展,已有大量证据显示癫痫的发生发展与皮质-皮质下神经网络密切相关。本文拟就丘脑、下丘脑、小脑、基底节、脑干等皮质下结构参与癫痫发生发展的相关研究,以及目前神经调控治疗耐药性癫痫所针对的重要皮质下神经核团靶点进行综述,以为发掘癫痫治疗新靶点提供帮助。With the rapid development of neuroelectrophysiology,neuroimaging and other technologies,a large amount of evidence has shown the occurrence and development of epilepsy was closely related to cortico-subcortical neural network.This paper aims to review the relevant studies on the involvement of subcortical structures such as thalamus,hypothalamus,cerebellum,basal ganglia and brainstem in the occurrence and development of epilepsy,as well as some important targets of subcortical nucleus for the treatment of drug-resistant epilepsy(DRE)by neuroregulation,in order to provide help for the exploration of new intervention targets for epilepsy treatment.

关 键 词：癫痫 大脑皮质 神经网 电刺激疗法 综述 

分 类 号：R742.1[医药卫生—神经病学与精神病学]