Neuronal guidance genes in health and diseases  

作　　者：Junichi Yuasa-Kawada Mariko Kinoshita-Kawada Yoshio Tsuboi Jane Y.Wu 

机构地区：[1]Department of Neurology,Fukuoka University,7.451 Nanakuma,Johnan.ku,Fukuoka 814-0180,Japan [2]Department of Neurology,Center for Genetic Medicine,Lurie Cancer Center,Northwestern University Feinberg School of Medicine,Ward Building Box 6117,303,E.Chicago Avenue,Chicago,Ilinois 60611.USA

出　　处：《Protein & Cell》2023年第4期238-261,共24页蛋白质与细胞（英文版）

摘　　要：Neurons migrate from their birthplaces to the destinations,and extending axons navigate to their synaptic targets by sensing various extracellular cues in spatiotemporally controlled manners.These evolutionally conserved guidance cues and their receptors regulate multiple aspects of neural development to establish the highly complex nervous system by mediating both short-and long-range cell-cell communications.Neuronal guidance genes(encoding cues,receptors,or downstream signal transducers)are critical not only for development of the nervous system but also for synaptic maintenance,remodeling,and function in the adult brain.One emerging theme is the combinatorial and complementary functions of relatively limited classes of neuronal guidance genes in multiple processes,including neuronal migration,axonal guidance,synaptogenesis,and circuit formation.Importantly,neuronal guidance genes also regulate cell migration and cell-cell communications outside the nervous system.We are just beginning to understand how cells integrate multiple guidance and adhesion signaling inputs to determine overall cellular/subcellular behavior and how aberrant guidance signaling in various cell types contributes to diverse human diseases,ranging from developmental,neuropsychiatric,and neurodegenerative disorders to cancer metastasis.We review classic studies and recent advances in understanding signaling mechanisms of the guidance genes as well as their roles in human diseases.Furthermore,we discuss the remaining chalienges and therapeutic potentials of modulating neuronal guidance pathways in neural repair.

关 键 词：axon guidance neuronal migration SYNAPTOGENESIS neural circuit formation neural mapping cell-cell communications ANGIOGENESIS ORGANOGENESIS cancermetastasis 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]