首发青年重度抑郁症患者脑白质结构网络分析  

Analysis of the White Matter Structure Network in Treatment-naive Adults with Depression

作　　者：王梦莉 潘晓龙 张婷婷[1] WANG Meng-li;PAN Xiao-long;ZHANG Ting-ting(Department of Radiology,People's Hospital of China Three Gorges University,First People's Hospital of Yichang)

机构地区：[1]三峡大学人民医院·宜昌市第一人民医院放射科,湖北宜昌443000

出　　处：《神经损伤与功能重建》2023年第5期274-278,共5页Neural Injury and Functional Reconstruction

基　　金：宜昌市医疗卫生研究项目(No.A20-2-025)。

摘　　要：目的:探讨首发未经治疗青年重度抑郁症患者的脑功能网络变化特征。方法:收集24例首发重度抑郁症患者(抑郁症组)及年龄、性别、受教育年限相匹配的25例健康志愿者(健康对照组),采用汉密尔顿抑郁量表(HAMD)对2组进行抑郁严重程度评定,2组均行头颅磁共振弥散张量成像(DTI)扫描,通过图论方法构建大脑网络,计算相关网络指标,应用Gretna的对模块进行估计,比较2组脑网络属性和模块化特征。结果:抑郁症组同配性较健康对照组增高(t=2.391,P=0.024);抑郁症组左侧补充运动区、右侧颞上回的介中心性值较健康对照组增高(t=2.564,P=0.016;t=2.636,P=0.014);抑郁症组左侧额上回、左侧颞中回、左侧枕中回、左侧中央旁小叶的节点效率较健康对照组降低(t=2.038,P=0.049;t=2.174,P=0.046;t=2.262,P=0.032;t=2.043,P=0.048);抑郁症组右侧杏仁核、左侧脑岛、左侧缘上回的节点最短路径降低(t=2.079,P=0.047;t=2.086,P=0.047;t=2.244,P=0.034)。连边分析显示,抑郁症组右侧尾状核、右侧豆状壳核的连边强度较健康对照组下降(P=0.000;P=0.000);右侧颞上回的介中心性值与HAMD评分呈负相关(r=-0.635,P=0.012)。结论:抑郁症组的脑网络发生异常,与抑郁症相关的某些脑区功能发生改变和重组有关,局部脑区功能可出现代偿。Objective:To explore the characteristics of the brain function network in treatment-naive young and middle-aged patients with depression.Methods:Twenty-four patients with major depression and 25healthy volunteers were enrolled in this study.The severity of depression was assessed using the Hamilton depression scale(HAMD).All participants underwent DTI scanning,their brain networks were constructed using the graph theory method,the relevant network indexes were calculated,and the modules were estimated by Gretna's method.Finally,the brain network attributes and modular characteristics of the two groups were compared.Results:Compared with the healthy control group,patients with major depression had higher homozygosity(t=2.391,P=0.024);higher median values of left supplementary motor area and right superior temporal gyrus(t=2.564,P=0.016);and lower node efficiency of the left superior frontal gyrus,left middle temporal gyrus,left middle occipital gyrus,and left paracentral lobule.Further,the shortest path of nodes in the right amygdala,left insula,and left superior marginal gyrus was decreased in patients with major depression(t=2.038,P=0.049;t=2.174,P=0.046;t=2.262,P=0.032;t=2.043,P=0.048),and edge connectivity analysis showed that the edge connectivity of the right caudate nucleus and the right lenticular putamen in patients with major depression was lower than that in healthy controls(P=0.000;P=0.000).Finally,we identified negative correlations between the median value of right superior temporal gyrus and Hamilton Depression Scale scores(r =-0.635,P=0.012).Conclusion:The brain network of patients with major depression is abnormal;the functions of some brain regions related to major depression are altered and show recombination,for which local brain regions may compensate.

关 键 词：抑郁症 磁共振 脑网络 图论 

分 类 号：R741[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]