西澳菲斯特农场赤桉蜂蜜对大肠埃希菌腹泻小鼠模型的影响  

Effect of Fewster’s Farm Jarrah Honey on Hydropiperis Herba Diarrhea Mouse Model

作　　者：张雷雷 林韦康 ZHANG Leilei;LIN Weikang(Wang Shuhe(Zhengzhou)Biopharmaceutical Engineering Co.,Ltd.,Zhengzhou 450000,China;Wang Shuhe Biomedical(Wuhan)Co.,Ltd.,Wuhan 430040,China)

机构地区：[1]王叔和(郑州)生物制药工程有限公司,河南郑州450000 [2]王叔和生物医药(武汉)有限公司,湖北武汉430040

出　　处：《食品安全导刊》2023年第12期117-120,共4页China Food Safety Magazine

摘　　要：目的:为了探讨西澳菲斯特农场赤桉蜂蜜(Fewster’s Farm Jarrah Honey,FFJH)改善大肠埃希菌腹泻小鼠肠道的作用效果。方法:采用大肠埃希菌注射塑造相关性腹泻小鼠模型,分为正常组、模型组、诺氟沙星组、市售蜂蜜组、FFJH组,成功建模后测定各组小鼠腹泻率、腹泻指数、体质量、小肠推进率和血清胃肠激素含量。结果:相对于正常组,模型组小鼠腹泻指数明显增加(P<0.01);相对于模型组,诺氟沙星组、市售蜂蜜高剂量组、FFJH低中高剂量组小鼠腹泻指数均有所减少,有显著性差异(P<0.01);相比模型组,FFJH低中高剂量组体质量有显著性差异(P<0.01);FFJH中高剂量组MTL含量明显升高(P<0.01);FFJH中高剂量组显著降低了小鼠血清VIP含量(P<0.01)。结论:FFJH对大肠埃希菌腹泻有显著效果,可通过调节小鼠肠道环境和修复肠道微生态,改善小鼠腹泻的临床症状。Objective:In order to explore the effect of Fewster’s Farm jarrah honey on improving the intestinal tract of mouse with Escherichia coli diarrhea.Method:The model of diarrhea related mouse was established by injection of Escherichia coli,which was divided into normal group,model group,norfloxacin capsule group,commercially available honey group,and FFJH group.After successful modeling,the diarrhea mouse,diarrhea index,body mass,small intestine propulsion mouse and serum gastrointestinal hormone content of mouse in each group were determined.Result:Compared with the normal group,the diarrhea index of the model group was significantly increased(P<0.01),while compared with the model group,the diarrhea index of the Norfloxacin group,the high dose honey group and the low,middle and high dose FFJH group were decreased,compared with the model group,the body weight of FFJH low,middle and high dose group had significant difference(P<0.01).The content of MTL in high dose FFJH group was significantly increased(P<0.01),and the content of VIP in serum was significantly decreased in high dose FFJH group(P<0.01).Conclusion:FFJH has significant effect on diarrhea caused by Escherichia coli.It may improve the clinical symptoms of diarrhea in mouse by regulating the intestinal environment and repairing intestinal microecology.

关 键 词：西澳菲斯特农场赤桉蜂蜜 大肠埃希菌 小鼠腹泻模型 

分 类 号：R574.62[医药卫生—消化系统] TS201.4[医药卫生—内科学]